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Comparison of novel risk factors for cardiovascular disease between hemodialysis patients with and without protein-energy wasting

  • Nephrology - Original Paper
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Abstract

Purpose

The present study was designed to compare novel risk factors for cardiovascular diseases (CVD) between hemodialysis (HD) patients with or without protein-energy wasting (PEW) for determining novel risk factors for CVD in HD patients with PEW.

Methods

In this cross-sectional study, 291 HD patients were randomly selected from among 2,302 adult HD patients in Tehran hemodialysis centers. The presence of PEW in HD patients was determined by subjective global assessment. In addition, 4 mL blood was obtained before dialysis and analyzed for serum concentrations of novel risk factors for CVD, including C-reactive protein (CRP), soluble intercellular adhesion molecule type 1 (sICAM-1), soluble vascular cell adhesion molecule type 1 (sVCAM-1), sE-selectin, malondialdehyde (MDA), nitric oxide (NO), endothelin-1 and lipoprotein (a) [Lp (a)].

Results

Serum CRP and sICAM-1 were significantly higher in HD patients with PEW as compared to those without PEW (P < 0.01), whereas there were no significant differences in serum sVCAM-1, sE-selectin, MDA, NO, endothelin-1 and Lp (a) between the two groups. Serum CRP and sICAM-1 were significantly higher in HD patients with PEW type IIa and IIb than in those with PEW type I (P < 0.01).

Conclusion

The present study indicates that serum CRP and sICAM-1, as two CVD risk factors, increase in HD patients with PEW as compared to those without PEW and these increases occur in HD patients with PEW type IIa and IIb who have inflammation.

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Acknowledgments

This study was supported by National Nutrition and Food Technology Research Institute of Iran. The authors thank the staff of the Tehran hemodialysis centers for their invaluable assistance and the staff of the research laboratory of Research Institute for Endocrine Sciences for their technical assistance.

Conflict of interest

The authors declare that they have no conflict of interest.

Author information

Authors and Affiliations

  1. Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, 46, West Arghavan St., Farahzadi Blvd., Shahrak Qods, P.O. Box: 19395-4741, Tehran, Islamic Republic of Iran

    Hadi Tabibi

  2. Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran

    Atefeh As’habi

  3. Department of Nephrology, Tehran University of Medical Sciences, Tehran, Iran

    Mitra Mahdavi-Mazdeh

  4. Research Institute for Endocrine Sciences, Cellular and Molecular Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Mehdi Hedayati

  5. Iranian Tissue Bank, Research and Preparation Center, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran

    Behnaz Nozary-Heshmati

Authors
  1. Hadi Tabibi
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  2. Atefeh As’habi
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  3. Mitra Mahdavi-Mazdeh
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Correspondence to Hadi Tabibi.

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Tabibi, H., As’habi, A., Mahdavi-Mazdeh, M. et al. Comparison of novel risk factors for cardiovascular disease between hemodialysis patients with and without protein-energy wasting. Int Urol Nephrol 46, 2015–2020 (2014). https://doi.org/10.1007/s11255-014-0750-x

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  • DOI: https://doi.org/10.1007/s11255-014-0750-x

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