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High-sensitivity C-reactive protein, apolipoproteins, and residual diuresis in chronic kidney disease patients undergoing hemodialysis

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Abstract

Background

Residual diuresis (RD) is the simplest method for measuring renal residual function in patients with chronic kidney disease (CKD). A reduction in RD is associated with intensification of the inflammatory process caused by uremia. However, little is known regarding the relation between RD and inflammatory markers in these patients. We verify possible associations among the hs-CRP, atherogenic factors, and RD, in patients with CKD undergoing hemodialysis.

Methods

This study enrolled 80 patients with CKD undergoing hemodialysis. Patients were stratified according to RD in anuric (RD−) group (n = 47) and non-anuric (RD+) group (n = 33). Urine volumes were collected in a 24 h period during the interdialytic period. Serum high-sensitivity C-reactive protein (hs-CRP), and apolipoprotein (Apo) A1 and B levels were measured after fasting for 12 h.

Results

Serum hs-CRP levels were higher in the RD− group than in the RD+ group (P = 0.015). In the total group, hs-CRP was significantly correlated with RD (r = − 0.25, P = 0.025) and Apo AI (r = − 0.25, P = 0.024). A greater proportion of patients had reduced plasma concentrations of Apo AI in the RD− group (31.9 %) compared with the RD+ group (9.1 %) (P = 0.014).

Conclusion

This study shows a relationship between RD and the hs-CRP in patients undergoing hemodialysis. Although the inflammatory state was verified in a large part of the CKD population, patients without RD had more elevated hs-CRP serum levels than those with RD.

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Acknowledgments

We acknowledge the staff of Nefroclínica de Uberlandia for collaboration and the Mathematics Faculty of Federal University of Uberlândia for help with biostatistics. We especially thank all of the patients who participated in this study.

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Authors and Affiliations

  1. Internal Medicine Department, Federal University of Uberlândia, Uberlândia, MG, Brazil

    Daniela Lemos Borges & Sebastião Rodrigues Ferreira Filho

  2. Research Unit, Nefroclínica de Uberlândia, Uberlândia, Minas Gerais, Brazil

    Helton Pereira Lemes, Valéria de Castro Ferreira & Sebastião Rodrigues Ferreira Filho

Authors
  1. Daniela Lemos Borges
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  2. Helton Pereira Lemes
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  3. Valéria de Castro Ferreira
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  4. Sebastião Rodrigues Ferreira Filho
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Correspondence to Sebastião Rodrigues Ferreira Filho.

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Borges, D.L., Lemes, H.P., de Castro Ferreira, V. et al. High-sensitivity C-reactive protein, apolipoproteins, and residual diuresis in chronic kidney disease patients undergoing hemodialysis. Clin Exp Nephrol 20, 943–950 (2016). https://doi.org/10.1007/s10157-016-1230-7

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  • DOI: https://doi.org/10.1007/s10157-016-1230-7

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