Skip to main content

Advertisement

SpringerLink
Log in

Histological Characterization of HCV-Associated Glomerulopathy in Egyptian Patients

  • Published:
International Urology and Nephrology Aims and scope Submit manuscript

Abstract

Background: HCV infection in Egypt has reached epidemic proportion, it is associated with many extra hepatic manifestations. Glomerulonephritis (GN) is one of the most serious ending in renal failure in some cases. Detection of viral genome or particles within the kidneys of HCV-infected patients proved to be difficult. Histological characterization of renal lesions still represents a major challenge. The aim of our work was to describe the histological patterns of HCV-associated nephropathy. Methods: Fifty patients – out of 233 presented to Mansoura Urology and Nephrology clinic with manifestations of glomerular disease were screened for HCV antibodies by 3rd generation ELISA test-, those proved positive for HCV antibodies were confirmed by PCR for HCV RNA and were thoroughly investigated regarding clinical, biochemical, histological criteria’s of HCV-associated nephropathy. Kidney and liver biopsies were examined by LM and electron microscopy. Results: Histological study of renal biopsies revealed membranoproliferative (MPGN) type 1 to be the commonest lesion encountered (54), followed by focal segmental glomerulosclerosis (FSGS) (24), mesangioproliferative GN (18), membranous nephropathy (MN) (4) in that order. Electron microscopic examinations of renal biopsies were successful in identifying HCV-like particles in frozen renal tissue. Conclusion: HCV-associated glomeruloapthy is a distinct category of glomerulonephritis, by LM it has some peculiar features, we were successful in localization of HCV particles in renal tissues by EM.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. C Frank Mk Mohamed GT Strickland et al. (2000) ArticleTitleThe role of parenteral antischistosomal therapy in the spread of hepatitis C virus in Egypt Lancet 355 887–891 Occurrence Handle10.1016/S0140-6736(99)06527-7 Occurrence Handle10752705

    Article  PubMed  Google Scholar 

  2. Zakaria S, Kamel M, Abdel-Wahab MF. Frequency of anti-HCV in the general population and in selected groups in Egypt. Paper presented at the Afro-Arab Conference on Liver and Biliary Disease, Cairo, Egypt, 6–13 February, 1993.

  3. RA. Wilson (1997) ArticleTitleExtrahepatic manifestations of chronic viral hepatitis Am J Gastroenterol 92 4–15

    Google Scholar 

  4. I Ohsawa H Ohi M Endo et al. (1999) ArticleTitleHigh prevalence of hepatitis C virus antibodies in elder patients with membranoproliferative glomerulonephritis Nephron 82 366–367 Occurrence Handle10.1159/000045459 Occurrence Handle10450046

    Article  PubMed  Google Scholar 

  5. RJ Johnson DR Gretch WG Couser et al. (1994) ArticleTitleHepatitis C virus associated glomerulonephritis Effect of alpha-interferon therapy. Kid Int 46 1700–1704

    Google Scholar 

  6. IH Altraif AS Abdulla MI Alsebayl et al. (1995) ArticleTitleHepatitis C associated glomerulonephritis Am J Nephrol 15 407–410 Occurrence Handle7503140

    PubMed  Google Scholar 

  7. C Stehman-Breen CE Alpres WG Couser et al. (1995) ArticleTitleHepatitis C virus associated membranous glomerulonephritis Clinincal Nephrology 44 IssueID3 141–147

    Google Scholar 

  8. A Kamatsoda H Imai H Wahui et al. (1996) ArticleTitleClinicopathological analysis and therapy in HCV associated nephropathy Int J Med 35 529–533

    Google Scholar 

  9. L Daghestani C. Pomeroy (1999) ArticleTitleRenal manifestations of hepatitis C infection The Am J Med 106 347–354 Occurrence Handle10.1016/S0002-9343(99)00014-5

    Article  Google Scholar 

  10. MB Stokes H Chawla RI Brody et al. (1997) ArticleTitleImmune complex glomerulonephritis in patients coinfected with human immunodeficiency virus and hepatitis C virus Am J Kidney Dis 29 IssueID4 514–525 Occurrence Handle9100039

    PubMed  Google Scholar 

  11. D Sansonno V Cornacchiulo AR Lacobelli et al. (1995) ArticleTitleLocalization of hepatitis C virus antigens in liver and skin tissues of chronic hepatitis C virus-infected patients with mixed cryoglobulinemia Hepatology 21 305–312 Occurrence Handle10.1016/0270-9139(95)90085-3 Occurrence Handle7843698

    Article  PubMed  Google Scholar 

  12. D Sansonno AR Iacobelli V Cornacchiulo et al. (1996) ArticleTitleDetection of hepatitis C virus proteins by immunofluorescence and HCV RNA genomic sequences by non isotopic in situ hyberidization in bone marrow and peripheral blood mononuclear cells of chronically HCV-infected patients Clin Exp Immunol 103 414–420 Occurrence Handle8608640

    PubMed  Google Scholar 

  13. k Okada Y Takishita H Shimomura et al. (1996) ArticleTitleDetection of hepatitis C virus core protein in the glomeruli of patients with membranous gloerulonephritis Clin Nephrol 45 IssueID2 71–76 Occurrence Handle10.1159/000063230 Occurrence Handle8846533

    Article  PubMed  Google Scholar 

  14. Bandi L. Postgraduate Medicine, Vol. 113, No. 2, February 2003.

  15. MA Darwish TA Raouf P Roushdy et al. (1993) ArticleTitleRisk factors associated with a high seroprevalence of hepatitis C virus infection in Egyptian blood donors Am J Trop Med Hyg 49 440–447 Occurrence Handle7692754

    PubMed  Google Scholar 

  16. G D’Amico G Colasanti F Ferrario RA. Sinico (1989) ArticleTitleRenal involvement in essential mixed cryoglobulinemia Kidney Int 35 1004–1014 Occurrence Handle2651764

    PubMed  Google Scholar 

  17. RJ Johnson DR Gretch H Yamabe et al. (1993) ArticleTitleMembranoproliferative glomerulonephritis associated with hepatitis C virus infection N Engl J Med 328 465–470 Occurrence Handle10.1056/NEJM199302183280703 Occurrence Handle7678440

    Article  PubMed  Google Scholar 

  18. G Akyol S Dash YS Shieh et al. (1992) ArticleTitleDetection of hepatitis C virus RNA sequences by polymerase chain reaction in fixed liver tissue Mod Pathol 5 501–504 Occurrence Handle1344813

    PubMed  Google Scholar 

  19. V Agnello RT Chung LM. Kaplan (1992) ArticleTitleA role for hepatitis C virus infection in type ΙΙ cryoglobulinemia N Engl J Med 19 1490–1495

    Google Scholar 

  20. YSC Shieh KS Shim P Lampertico LJ. Jeffers (1991) ArticleTitleDetection of hepatitis C virus sequences in liver tissues by polymerase chain reaction Lab Invest 65 408 Occurrence Handle1656140

    PubMed  Google Scholar 

  21. C Bosman MB Valli L Bertolini et al. (1998) ArticleTitleDetection of virus like particles in liver biopsies from HCV-infected patients Res Virol 149 311–314 Occurrence Handle10.1016/S0923-2516(99)89011-6 Occurrence Handle9879610

    Article  PubMed  Google Scholar 

  22. S Horikoshi T Okada I Shirato et al. (1993) ArticleTitleDiffuse proliferative glomerulonephritis with hepatitis C virus like particles in paramesangial dense deposits in a patient with chronic hepatitis C virus Nephron 64 462–464 Occurrence Handle8393534

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Nephrology, Mansoura Urology and Nephrology center, Mansoura University, Egypt

    Alaa Sabry, Amgad El-Agroudy, Hussein Sheashaa, Amr El-husseini & Mohamed Sobh

  2. Department of pathology, Mansoura Urology and Nephrology center, Mansoura University, Egypt

    Nohir Mostafa Taha & Mahmoud Elbaz

  3. Department of Clinical biochemistry, Mansoura Urology and Nephrology Centre, Mansoura University, Egypt

    Fagr El-Shahat

Authors
  1. Alaa Sabry
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Amgad El-Agroudy
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Hussein Sheashaa
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Amr El-husseini
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Nohir Mostafa Taha
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Mahmoud Elbaz
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Fagr El-Shahat
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Mohamed Sobh
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Alaa Sabry.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sabry, A., El-Agroudy, A., Sheashaa, H. et al. Histological Characterization of HCV-Associated Glomerulopathy in Egyptian Patients. Int Urol Nephrol 37, 355–361 (2005). https://doi.org/10.1007/s11255-004-4096-7

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11255-004-4096-7

Keywords:

Search

Navigation