Skip to main content

Advertisement

SpringerLink
Log in

Sobh Formula: A New Formula for Estimation of Creatinine Clearance in Healthy Subjects and Patients with Chronic Renal disease

  • Published:
International Urology and Nephrology Aims and scope Submit manuscript

Abstract

Backgrounds: Cockcroft–Gault formula overestimates creatinine clearance (Ccr) in obese or edematous patients. This limitation urged us to develop a new formula that can overcome the limitation of Cockcroft–Gault formula. Methods: We developed a new formula suitable for rapid bedside estimation of creatinine clearance in healthy adults and elderly persons and patients with chronic renal disease considering the surface area as a reliable factor for estimation of creatinine clearance. This cross sectional study included 182 individuals (healthy persons and patients with chronic kidney disease). Ccr was estimated by different methods including 24 hours urine collection, Cockcroft–Gault equation, and our new formula, and 99mTc-DTPA isotope clearance which was considered as a standard method for comparison between the other methods.

Results: Our new formula had a statistically significant higher correlation coefficient with the standard 99mTc-DTPA isotope clearance for all groups included in this study (r=0.97) than either Cockcroft–Gault formula (r=0.90) or 24 hours urine collection method (r=0.88). Conclusion: Our formula is a step forward for a better bedside assessment of kidney function in both healthy individuals and patients with chronic kidney disease.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Levey AS, Madaio MP, Perrone RD. (1995). Laboratory Assessement of Renal Disease: Clearance, Urinalysis and Renal Biopsy, The Kidney, 4th edn., Brenner & Rector, 1995; 919–937.

  2. AS. Levey (1989) ArticleTitleUse of glomerular filtration rate measurements to assess the progression of renal disease Semin Nephrol 9 370–379 Occurrence Handle2688012

    PubMed  Google Scholar 

  3. RD Perrone TI Steinman GJ Beck et al. (1990) ArticleTitleUtility of radioisotopic filtration markers in chronic renal insufficiency: simultaneous comparison of 125 I-iothalamate, 169yb-DTPA, 99m Tc-DTPA and inulin Am J Kidney Dis 16 224–235 Occurrence Handle2205098

    PubMed  Google Scholar 

  4. AS. Levey (1990) ArticleTitleMeasurement of renal function in chronic renal disease Kidney Int 38 167–184 Occurrence Handle2200925

    PubMed  Google Scholar 

  5. Smith HW. The reliability of inulin as a measure of glomerular filtration. In: The Kidney: Structure and Function in Health and Disease. New York: Oxford University Press, 1951: 231–238.

  6. PD Doolan EL Alpen GB. Theil (1962) ArticleTitleA clinical appraisal of the plasma concentration and endogenous clearance of creatinine Am J Med 32 65–79 Occurrence Handle10.1016/0002-9343(62)90183-3 Occurrence Handle13887292

    Article  PubMed  Google Scholar 

  7. RM Fawdry SM Gruenewald LT Collins AJ. Roberts (1985) ArticleTitleComparative assessment of techniques for estimation of glomerular filtration rate with 99mTcDTPA Eur J Nucl Med 11 7–12 Occurrence Handle10.1007/BF00440953 Occurrence Handle3899658

    Article  PubMed  Google Scholar 

  8. S Giovannetti G. Barsotti (1991) ArticleTitleIn defense of creatinine clearance Nephron 59 11–14 Occurrence Handle1944722

    PubMed  Google Scholar 

  9. M. Walser (1998) ArticleTitleAssessing renal function from creatinine measurements in adults with chronic renal failure Am J Kidney Dis 32 23–31 Occurrence Handle9669420

    PubMed  Google Scholar 

  10. DW Cockcroft MH. Gault (1976) ArticleTitlePrediction of creatinine clearance from serum creatinine Nephron 16 31–41 Occurrence Handle1244564

    PubMed  Google Scholar 

  11. HA Rolin PM Hall R. Wei (1984) ArticleTitleInaccuracy of estimated creatinine clearance for prediction of iothalamate glomerular filtration rate Am J Kidney Dis 4 IssueID1 48–54 Occurrence Handle6741937

    PubMed  Google Scholar 

  12. GB Haycock GJ Schwartz DH. Wisotsky (1978) ArticleTitleGeometric method for measuring body surface area: a height–weight formulas validated in infants, children and adults J Pediatr 93 62–66 Occurrence Handle650346

    PubMed  Google Scholar 

  13. M Rehling ML Moller B Thamdrup et al. (1984) ArticleTitleSimultaneous measurement of renal clearance and plasma clearance of 99mTc-labeled diethylenetriaminepenta-acetate. 51 Cr-labeled ethylenediaminetetra-acetate and inulin in man Clin Sci 66 613–619 Occurrence Handle6423339

    PubMed  Google Scholar 

  14. NG Santo ParticleDe P Anastasio M Cirillo et al. (1999) ArticleTitleMeasurement of glomerular filtration rate by 99mTc-DTPA renogram is less precise than measured and predicted creatinine clearance Nephron 81 IssueID2 136–140 Occurrence Handle10.1159/000045268 Occurrence Handle9933747

    Article  PubMed  Google Scholar 

  15. A Piepsz A Dobbeleir F. Erbsmann (1977) ArticleTitleMeasurement of separate kidney clearance by means of 99mTc-DTPA complex and a scintillation camera Eur J Nucl Med 2 IssueID3 173–177 Occurrence Handle10.1007/BF00257276 Occurrence Handle913431

    Article  PubMed  Google Scholar 

  16. GF. Gates (1982) ArticleTitleGlomerular filtration rate: estimation from fractional accumulation of 99mTc-DTPA Am J Roentgenol 138 IssueID3 565–570

    Google Scholar 

  17. RM Shore SA Koff JR Hayes et al. (1986) ArticleTitleGlomerular filtration in children: validation and longitudinal use of of determination from the 99mTc-DTPA renogram Am J Kidney Dis 8 IssueID3 170–180 Occurrence Handle3529943

    PubMed  Google Scholar 

  18. A Donahue JS McCune S Faucette et al. (2001) ArticleTitleMeasured versus estimated glomerular filtration rate in the Calvert equation: influence on carboplatin dosing Cancer Chemother Pharmacol 47 IssueID5 373–379 Occurrence Handle10.1007/s002800000260 Occurrence Handle11391850

    Article  PubMed  Google Scholar 

  19. LJ Petersen JR Petersen U Talleruphuus et al. (1999) ArticleTitleGlomerular filtration rate estimated from the uptake phase of 99mTc-DTPA renography in chronic renal failure Nephrol Dial Transplant 14 1673–1678 Occurrence Handle10.1093/ndt/14.7.1673 Occurrence Handle10435875

    Article  PubMed  Google Scholar 

  20. RA Parker WM Bennett GA. Porter (1980) ArticleTitleClinical estimation of creatinine clearance without urine collection Dial Transplant 9 251–252

    Google Scholar 

  21. C Chantler TM. Barratt (1972) ArticleTitleEstimation of the glomerular filtration rate from the plasma clearance of 51-Chromium edetic acid Arch Dis Childhood 47 613–617

    Google Scholar 

  22. AM El-Nahas GA. Coles (1986) ArticleTitleDietary treatment of chronic renal failure: ten unanswered questions Lancet 1 597–600 Occurrence Handle10.1016/S0140-6736(86)92819-9 Occurrence Handle2869311

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Nephrology, Urology and Nephrology Center, Mansoura University, Mansoura, Egypt

    Mohamed Sobh, Ahmed Neamatallah, Hussein Sheashaa, Ahmed Akl & Yasser Osman

  2. Department of Radiology, Urology and Nephrology Center, Mansoura University, Mansoura, Egypt

    Hossam Gad

  3. Department of Mathematics, Faculty of Science, Mansoura University, Mansoura, Egypt

    Mohamed Eletrby & Ahmed Hegazy

Authors
  1. Mohamed Sobh
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ahmed Neamatallah
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Hussein Sheashaa
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Ahmed Akl
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Yasser Osman
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Hossam Gad
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Mohamed Eletrby
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Ahmed Hegazy
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Mohamed Sobh.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sobh, M., Neamatallah, A., Sheashaa, H. et al. Sobh Formula: A New Formula for Estimation of Creatinine Clearance in Healthy Subjects and Patients with Chronic Renal disease. Int Urol Nephrol 37, 403–408 (2005). https://doi.org/10.1007/s11255-004-1262-x

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11255-004-1262-x

Keywords

Search

Navigation