Abstract
Co-infections caused by trypanosomes and gastro-intestinal nematodes (GINs) compromise cattle productivity and their control requires a holistic approach. The effectiveness of trypanocides and anthelmintics is compromised by increasing resistance. Use of combined chemotherapeutic products for synergy, mainly practiced in human medicine, is gaining importance in livestock. A trial to evaluate efficacy of VERYL®, containing diminazene diaceturate (3.5 mg/kg body weight) and levamisole chloride (5 mg/kg body weight) for the control of GINs in cattle, was conducted at KALRO-VSRI Muguga, Kenya, between June and August 2016. Thirty-eight cattle aged between 6 and 12 months, naturally infected with GINs, were randomly allocated into two groups; a treatment group received VERYL® intra-muscularly at 10 mL/100 kg bwt and a control group which received Veriben® (Diminazene aceturate) at 3.5 mg/kg bwt. Faecal egg counts (FECs), coproculture, packed cell volume (PCV) and local tolerance at the injection site were measured during the study. FECs were comparable between the treatment and control groups at day 0. However, treatment of cattle with VERYL significantly (p < 0.001) reduced FECs by day 7 and sustained to day 21 post-treatment. Coproculture results for the treatment and control groups revealed presence of Haemonchus, Cooperia, Ostertagia, Trichostrongylus and Oesophagostomum species. Cattle treated with VERYL® had a significant (p < 0.05) reduction in larval recoveries compared to the control group. VERYL® had minimal adverse effects which cleared after a short while and is thus recommended for controlling GINs in cattle.
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CEVA and KALRO scientific teams participated in development of trial protocol and data collection tools. CEVA Santé Animale financed the work and KALRO team implemented the trial protocol.
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All authors contributed to study conception and design, development of trial protocol and data collection tools. KALRO team drafted the manuscript and all authors gave their comments.
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The Institutional Animal Care and Use Committee (IACUC) of KALRO-Muguga approved the study protocol and use of animals. The barn house was well-ventilated, had adequate lighting, feeding and watering troughs, walk-in weighing scale and secure animal handling crush. Rhodes grass and water was provided ad libitum and animals were supplemented with concentrates and minerals.
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Authors from KALRO declare that they have no competing interests. A Caruso-Varès, G Pagny, Chevtzoff Collin and N Isaka are employed by Ceva Santé Animale which sponsored and ran this study.
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Maichomo, M.W., Nginyi, J.M., Caruso-Varès, A. et al. Efficacy of VERYL® in the treatment of cattle naturally infected with gastro-intestinal nematodes in Kenya. Trop Anim Health Prod 52, 1699–1705 (2020). https://doi.org/10.1007/s11250-019-02179-4
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DOI: https://doi.org/10.1007/s11250-019-02179-4