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Effects of Ferula asafetida, closantel, albendazole, oxfendazole, and ivermectin against Haemonchus contortus in goats and sheep

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Abstract

Background

Haemonchosis is a fatal disease of small ruminants caused by the parasite Haemonchus contortus (H. contortus). The most common drugs used in the treatment of H. contortus include albendazole, oxfendazole, and ivermectin. However, as previously reported in the treatment of haemonchosis, these medicines have acquired drug resistance problems over time. Interestingly, natural plant compounds have demonstrated promising effects in the treatment of H. contortus. Therefore, the current study evaluated the effects of plant extract, Ferula asafetida, against common drugs such as albendazole, oxfendazole, ivermectin, and closantel for the treatment of haemonchosis in small ruminants.

Methodology

The current study was conducted on different small ruminant farms in Kasur District, Punjab, Pakistan. The positive animals (n = 720) after coprological examination were selected in this study and divided into two major groups (n = 360 goats and n = 360 sheep). Further, animals were divided into five treatment groups (A–E) and one control group with no treatment (F). Albendazole, oxfendazole, ivermectin, closantel, and Ferula asafetida were administered orally to groups A–E, respectively. The eggs per gram feces (EPG) were determined through the McMaster technique on days 0, 7th, and 14th of treatment.

Results

The results showed a significantly higher efficacy of closantel and Ferula asafetida against H. contortus in both goats (100% and 70%; p < 0.05) and sheep (99% and 87%; p < 0.05), respectively. No correlation was observed between EPG reduction with age and gender in both goats and sheep.

Conclusion

Allopathic drug closantel and herbal drug, Ferula asafetida, have been proved an effective dewormer against H. contortus in small ruminants.

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Data availability

The numerical data used to support the findings of this study are available from the first author upon request.

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Acknowledgements

The authors highly acknowledged the Central Laboratory Complex (CLC) UVAS Ravi Campus Pattoki for providing research facilities to carry out some part of this work.

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Authors and Affiliations

  1. Department of Clinical Medicine, Faculty of Veterinary Science, University of Veterinary and Animal Sciences, Lahore, Punjab, Pakistan

    Abdul Jabbar, Muhammad Zahid Iqbal, Aneela Zameer Durrani, Muhammad Imran & Muhammad Shair Zaman Ghauri

  2. Department of Theriogenology, Faculty of Veterinary Sciences, University of Veterinary and Animal Sciences, Lahore, Punjab, Pakistan

    Muhammad Ashraf

  3. Department of Food Science and Human Nutrition, Faculty of Bio Sciences, University of Veterinary and Animal Sciences, Lahore, Punjab, Pakistan

    Hira Sajjad

  4. Department of Biological Sciences, Faculty of Science, Abubakar Tafawa Balewa University, Bauchi, Nigeria

    Mohammed Nasiru Wana

  5. Department of Pathology, University of Veterinary and Animal Sciences, Lahore, Punjab, Pakistan

    Asad Ullah

  6. Department of Animal Breeding and Genetics, University of Veterinary and Animal Sciences, Ravi Campus, Pattoki, Punjab, Pakistan

    Hafiz Ishfaq Ahmad

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  1. Abdul Jabbar
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Contributions

HIA conceived and designed the research. AJ and MZI conducted experiments. MA and MNW analyzed data. AJ, HS, MI, and MSZG wrote the manuscript. All authors read and approved the manuscript. AZD and AU revised the manuscript.

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Correspondence to Hafiz Ishfaq Ahmad.

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Jabbar, A., Iqbal, M.Z., Ashraf, M. et al. Effects of Ferula asafetida, closantel, albendazole, oxfendazole, and ivermectin against Haemonchus contortus in goats and sheep. Trop Anim Health Prod 54, 107 (2022). https://doi.org/10.1007/s11250-022-03111-z

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