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Exploration of Bioactive Compounds from Sargassum myriocystum; A Novel Approach on Catalytic Inhibition Against Free Radical Formation and Glucose Elevation

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Abstract

The importance of bioactive substances from seaweeds has grown as a result of their capacity to promote human disease resistance and enhance human health. Secondary metabolites from brown marine algae could serve as a good source of phytochemicals with rich anti-oxidant ability, as most of the ailments are associated with free radicals. This research is focused on looking into the brown algal species Sargassum myriocystum belonging to the class Phaeophyceae, which has not been investigated for the presence of different bioactive compounds. The efficient extraction of and the qualitative analysis of the phytochemical compounds were performed and characterized. Moreover, the characteristic functional and bioactive molecules in the extract at optimum conditions were evaluated which showed the presence of various bioactive compounds. The antioxidant and anti-inflammatory potential of the extract indicated the potential reduction of free radicals and inflammatory mediators by the seaweed extract. The inhibition of digestive enzymes including α-amylase and α-glucosidase exhibited promising anti-diabetic potential and the antimicrobial property against some gram negative, gram positive bacteria and fungus was evaluated which inhibited the growth of microbes. Hence, the present study may provide the platform for utilizing bioactive compounds from brown seaweed as a promising therapeutic agent from natural source.

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References

  1. Tanna B, Mishra A (2018) Metabolites unravel nutraceutical potential of edible seaweeds: an emerging source of functional food. Compr Rev Food Sci Food Saf 17:1613–1624. https://doi.org/10.1111/1541-4337.12396

    Article  PubMed  Google Scholar 

  2. Wekre ME, Kasin K, Underhaug J, Holmelid B, Jordheim M (2019) Quantification of polyphenols in seaweeds: a case study of ulva intestinalis. Antioxidants (Basel) 8:612. https://doi.org/10.3390/antiox8120612

    Article  CAS  PubMed  Google Scholar 

  3. Mahendran S, Maheswari P, Sasikala V, Rubika JJ, Pandiarajan J (2021) In vitro antioxidant study of polyphenol from red seaweeds dichotomously branched gracilaria Gracilaria edulis and robust sea moss Hypnea valentiae. Toxicol Rep 8:1404–1411. https://doi.org/10.1016/j.toxrep.2021.07.006

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Lee JH, Kim HJ, Jee Y, Jeon YJ, Kim HJ (2020) Antioxidant potential of Sargassum horneri extract against urban particulate matter-induced oxidation. Food Sci Biotechnol. 29:855–865. https://doi.org/10.1007/s10068-019-00729-y

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Alara OR, Abdurahman NH, Ukaegbu CI (2018) Soxhlet extraction of phenolic compounds from Vernonia cinerea leaves and its antioxidant activity. J Appl Res Med Aromat Plants 11:12–17. https://doi.org/10.1016/j.jarmap.2018.07.003

    Article  Google Scholar 

  6. Jiang J, Jiang Z, Yan Q, Han S, Yang S (2023) Releasing bioactive compounds from brown seaweed with novel cold-adapted alginate lyase and alcalase. Mar Drugs 21(4):208. https://doi.org/10.3390/md21040208

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Princy BS, Benila TS, Shynin B, Jeeva S (2022) Green synthesis of nanoparticles from seaweeds—a literature review. J Pharm Negat. https://doi.org/10.47750/pnr.2022.13.S07.450

    Article  Google Scholar 

  8. Deepak P, Amutha V, Birundha R, Sowmiya R, Kamaraj C, Balasubramanian V, Balasubramani G, Aiswarya D, Arul D, Perumal P (2018) Facile green synthesis of nanoparticles from brown seaweed Sargassum wightii and its biological application potential. Adv Nat Sci 9(3):035019. https://doi.org/10.1088/2043-6254/aadc4a

    Article  CAS  Google Scholar 

  9. Debbarma J, Viji P, Rao BM, Ravishankar CN (2022) Seaweeds: potential applications of the aquatic vegetables to augment nutritional composition, texture, and health benefits of food and food products. In: RangaRao A, Ravishankar GA (eds) Sustainable global resources of seaweeds. 2. Springer, Cham. https://doi.org/10.1007/978-3-030-92174-3_1

    Chapter  Google Scholar 

  10. Rout S, Rath B, Kumar A, Bhattamisra SK, Panda JR (2020) Preliminary phytochemical analysis of the crude extract of Sargassum wightii. Int J Sci Res Eng Dev 5(11):227–230

    Google Scholar 

  11. Olivia NU, Goodness UC, Obinna OM (2021) Phytochemical profiling and GC–MS analysis of aqueous methanol fraction of Hibiscus asper leaves. Future J Pharm Sci 7:59. https://doi.org/10.1186/s43094-021-00208-4

    Article  Google Scholar 

  12. Silva J, Alves C, Freitas R, Martins A, Pinteus S, Ribeiro J, Gaspar H, Alfonso A, Pedrosa R (2019) Antioxidant and neuroprotective potential of the brown seaweed Bifurcaria bifurcata in an in vitro Parkinson’s disease model. Mar Drugs 17(2):85. https://doi.org/10.3390/md17020085

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Obluchinskaya ED, Pozharitskaya ON, Shikov AN (2022) In vitro anti-inflammatory activities of fucoidans from five species of brown seaweeds. Mar Drugs 20(10):606. https://doi.org/10.3390/md20100606

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Reka P, Azeez T, Seethalakshmi M (2017) Alpha amylase and alpha glucosidase inhibition activity of selected edible seaweeds from south coast area of India. Int J Pharm Pharm 9(6):64. https://doi.org/10.22159/ijpps.2017v9i6.17684

    Article  CAS  Google Scholar 

  15. Zaharudin N, Staerk D, Dragsted LO (2019) Inhibition of α-glucosidase activity by selected edible seaweeds and fucoxanthin. Food Chem 270:481–486. https://doi.org/10.1016/j.foodchem.2018.07.142

    Article  CAS  PubMed  Google Scholar 

  16. Baek SH, Cao L, Jeong SJ, Kim HR, Nam TJ, Lee SG (2021) The comparison of total phenolics, total antioxidant, and anti-tyrosinase activities of Korean Sargassum species. J Food Qual. https://doi.org/10.1155/2021/6640789

    Article  Google Scholar 

  17. Zhao JH, Xu XJ, Ji MH, Cheng JL, Zhu GN (2011) Design, synthesis, and biological activities of milbemycin analogues. J Agric Food Chem 59:4836–4850. https://doi.org/10.1021/jf2001926

    Article  CAS  PubMed  Google Scholar 

  18. Ahn YJ, Kim H (2021) Lutein as a modulator of oxidative stress-mediated inflammatory diseases. Antioxidants 10(9):1448. https://doi.org/10.3390/antiox10091448

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. Wu M, Ni L, Lu H, Xu H, Zou S, Zou X (2020) Terpenoids and their biological activities from cinnamomum: a review. J Chem. https://doi.org/10.1155/2020/5097542

    Article  Google Scholar 

  20. Lawson E, Kenneth I, Victor E, Lawson C, Victor E (2018) Antioxidant effects of astaxanthin in various diseases-a review. Oxid Antioxid Med Sci. https://doi.org/10.5455/oams.20180315075538

    Article  Google Scholar 

  21. Pereira AG, Otero P, Echave J, Carreira-Casais A, Chamorro F, Collazo N, Jaboui A, Lourenço-Lopes C, Simal-Gandara J, Prieto MA (2021) Xanthophylls from the sea: algae as source of bioactive carotenoids. Mar Drugs 19:188. https://doi.org/10.3390/md19040188

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  22. Chen QW, Zhang X, Gong T, Gao W, Yuan S, Zhang PC, Kong JQ (2019) Structure and bioactivity of cholestane glycosides from the bulbs of Ornithogalum saundersiae Baker. Phytochemistry 164:206–214. https://doi.org/10.1016/j.phytochem.2019.05.016

    Article  CAS  PubMed  Google Scholar 

  23. Mou Y, Meng J, Fu X, Wang X, Tian J, Wang M, Peng Y, Zhou L (2013) Antimicrobial and antioxidant activities and effect of 1-hexadecene addition on palmarumycin C2 and C3 yields in liquid culture of endophytic fungus Berkleasmium sp. Dzf12. Molecules 18(12):15587–15599. https://doi.org/10.3390/molecules181215587

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  24. Yaokang W, Xueqin L, Yanfeng L, Guocheng D, Long L (2020) Systems and synthetic metabolic engineering for production of biochemical. Syst Synth Metab Eng. https://doi.org/10.1016/B978-0-12-821753-5.00009-5

    Article  Google Scholar 

  25. Nasr Z, El-shershaby H, Sallam K, Abed K, Ghany IA, Sidkey N (2022) Evaluation of antimicrobial potential of tetradecane extracted from Pediococcus acidilactici DSM: 20284-CM isolated from curd milk. Egypt J Chem 65:705–713. https://doi.org/10.21608/ejchem.2021.92658.4385

    Article  Google Scholar 

  26. Lakshmegowda SB, Rajesh SK, Kandikattu HK, Nallamuthu I, Khanum F (2020) In vitro and in vivo studies on hexane fraction of Nitzschia palea, a freshwater diatom for oxidative damage protective and anti-inflammatory response. Rev Bras Farmacogn 30:189–201. https://doi.org/10.1007/s43450-020-00008-6

    Article  CAS  Google Scholar 

  27. Siswadi S, Saragih GS (2021) Phytochemical analysis of bioactive compounds in ethanolic extract of Sterculia quadrifida RBr. AIP Conf Proc 2353:030098. https://doi.org/10.1063/5.0053057

    Article  CAS  Google Scholar 

  28. Francis P, Chakraborty K (2020) Antioxidant and anti-inflammatory cembrane-type diterpenoid from Echinoidea sea urchin Stomopneustes variolaris attenuates pro-inflammatory 5-lipoxygenase. Med Chem Res 29:656–664. https://doi.org/10.1007/s00044-020-02511-w

    Article  CAS  Google Scholar 

  29. Islam MD, Rashid MD, Abu AM, Reza ASM, Rahman MD, Choudhury T (2021) The food ingredients of different extracts of Lasia spinosa (L.) Thwaites can turn it into a potential medicinal food. NFS J 25:56–69. https://doi.org/10.1016/j.nfs.2021.11.002

    Article  CAS  Google Scholar 

  30. Cagalj M, Skroza D, Tabanelli G, Ozogul F, Simat V (2021) Maximizing the antioxidant capacity of Padina pavonica by choosing the right drying and extraction methods. Processes 9:587. https://doi.org/10.3390/pr9040587

    Article  CAS  Google Scholar 

  31. Amaro HM, Pagels F, Tavares TG, Costa I, Sousa-Pinto I, Guedes AC (2022) Antioxidant and anti-inflammatory potential of seaweed extracts as functional ingredients. Hydrobiology 1(4):469–482. https://doi.org/10.3390/hydrobiology1040028

    Article  Google Scholar 

  32. Lee S, Youn K, Kim DH, Ahn MR, Yoon E, Kim OY, Jun M (2019) Anti-neuroinflammatory property of phlorotannins from Ecklonia cava on Aβ25-35-induced damage in PC12 cells. Mar Drugs 17:7. https://doi.org/10.3390/md17010007

    Article  CAS  Google Scholar 

  33. Seedevi P, Abirami RG, Moovendhan M, Mohan K, Sivasankar P, Loganathan S, Vairamani S, Shanmugam A (2020) Anti-diabetic activity of crude polysaccharide and rhamnose-enriched polysaccharide from G. lithophila on Streptozotocin (STZ)-induced in Wistar rats. Sci Rep 10:556. https://doi.org/10.1038/s41598-020-57486-w

    Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

  34. Shakambari G, Ashokkumar B, Varalakshmi P (2015) Phlorotannins from brown algae: inhibition of advanced glycation end products formation in high glucose induced Caenorhabditis elegans. Indian J Exp Biol 53(6):371–379

    PubMed  Google Scholar 

  35. Yang C, Chen Y, Chen M, Jia RB, Liu B, Zhao C (2017) The antidiabetic activity of brown seaweed sargassum confusum polysaccharide hydrolysates in insulin resistance HepG2 cells in vitro. Res J Biotechnol 12:1–9

    Google Scholar 

  36. Gazali M, Jolanda O, Husni A, Nurjanah MFAA, Zuriat SR (2023) In vitro α-amylase and α-glucosidase inhibitory activity of green seaweed Halimeda tuna extract from the coast of Lhok Bubon. Aceh Plants 12(2):393. https://doi.org/10.3390/plants12020393

    Article  CAS  PubMed  Google Scholar 

  37. Gunathilaka TL, Samarakoon K, Ranasinghe P, Peiris LDC (2020) Antidiabetic potential of marine brown algae—a mini review. J Diabetes Res. https://doi.org/10.1155/2020/1230218

    Article  PubMed  PubMed Central  Google Scholar 

  38. Ford L, Stratakos AC, Theodoridou K, Dick JTA, Sheldrake GN, Linton M, Corcionivoschi N, Walsh PJ (2020) Polyphenols from brown seaweeds as a potential antimicrobial agent in animal feeds. ACS Omega 5(16):9093–9103. https://doi.org/10.1021/acsomega.9b03687

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Acknowledgements

The authors would like to express their gratitude to the coastal field workers at Mandapam, Rameshwaram for supporting in the collection of seaweed.

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  1. Department of Biotechnology, Vel Tech Rangarajan Dr Sagunthala R&D Institute of Science and Technology, Vel Nagar, Avadi, Chennai, Tamil Nadu, 600062, India

    Maheswari Vinodkumar & Azhagu Saravana Babu Packirisamy

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Correspondence to Azhagu Saravana Babu Packirisamy.

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Vinodkumar, M., Packirisamy, A.S.B. Exploration of Bioactive Compounds from Sargassum myriocystum; A Novel Approach on Catalytic Inhibition Against Free Radical Formation and Glucose Elevation. Top Catal 67, 60–73 (2024). https://doi.org/10.1007/s11244-023-01831-6

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