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Development of Methodologies for Copper-Catalyzed C–O Bond Formation and Direct Cyanation of Aryl Iodides

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Abstract

We present a new methodology using copper(I) oxide as a catalyst in conjunction with cesium carbonate as a base for the preparation of diaryl and aryl–alkyl ethers. A range of aryl iodides, phenols and primary alcohols can be used as substrates and reactions are performed using microwave heating. We also present the use of Cu2Fe(CN)6 as both catalyst and cyanating agent for the direct conversion of aryl iodides to nitriles.

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Acknowledgements

This work was funded by the National Science Foundation (CAREER award CHE-0847262) and the University of Connecticut. The authors thank CEM Corp. for microwave equipment support.

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Authors and Affiliations

  1. Department of Chemistry, University of Connecticut, 55 North Eagleville Road, Storrs, CT, 06269-3060, USA

    Arshad Mehmood, William G. Devine & Nicholas E. Leadbeater

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  1. Arshad Mehmood
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  2. William G. Devine
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  3. Nicholas E. Leadbeater
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Correspondence to Nicholas E. Leadbeater.

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Mehmood, A., Devine, W.G. & Leadbeater, N.E. Development of Methodologies for Copper-Catalyzed C–O Bond Formation and Direct Cyanation of Aryl Iodides. Top Catal 53, 1073–1080 (2010). https://doi.org/10.1007/s11244-010-9535-3

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  • DOI: https://doi.org/10.1007/s11244-010-9535-3

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