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Copper-catalyzed intramolecular C–N coupling reaction of aryl halide with amide

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Abstract

An efficient and concise method for the ligand-free copper-catalyzed intramolecular C–N bond coupling was developed, which afforded various (NH)-phenanthridinones in good to excellent yields with tolerance of various substrates.

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Acknowledgment

We thank the Ministry of Science and Technology of Republic of China (MOST 103-2113-M-032-009-MY2) for financial support of this research.

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Authors and Affiliations

  1. Department of Chemistry, Tamkang University, New Taipei City, 25137, Taiwan, ROC

    Wei-Lin Chen, Yuan-Ye Jhang & Jen-Chieh Hsieh

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  1. Wei-Lin Chen
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  2. Yuan-Ye Jhang
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  3. Jen-Chieh Hsieh
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Correspondence to Jen-Chieh Hsieh.

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Chen, WL., Jhang, YY. & Hsieh, JC. Copper-catalyzed intramolecular C–N coupling reaction of aryl halide with amide. Res Chem Intermed 43, 3517–3526 (2017). https://doi.org/10.1007/s11164-016-2438-6

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  • DOI: https://doi.org/10.1007/s11164-016-2438-6

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