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Synthesis and characterization of iminophosphineplatinum(II) complexes of the type (κ2-P,N-2-Ph2PC6H4C(H)=NC6H4X)PtCl2 (X = OMe, F)

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Abstract

A series of iminophosphineplatinum(II) complexes have been prepared from pro-ligands derived from aniline derivatives containing electron-donating methoxy groups or electron-withdrawing fluorides and [PtCl2(η 2 − coe)]2 (coe = cis-cyclooctene). All new pro-ligands and metal complexes have been fully characterized, including an X-ray diffraction study for compound 11 (derived from para-methoxyaniline). Additionally, the molecular structure of a di-iminophosphineplatinum dication 11a has been determined. The platinum compounds showed no appreciable cytotoxic properties against two glioma cell lines using the MTT method.

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Acknowledgements

Thanks are gratefully extended to Mount Allison University, Saint Mary’s University, Université de Moncton, the Natural Science and Engineering Research Council of Canada (SAW, JM, PJM) and the Canada Research Chair Programme (SAW) for financial support. We also thank Deman Durant (Mount Allison University) for his expert technical assistance, and anonymous reviewers are thanked for their very helpful comments.

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Authors and Affiliations

  1. Département de chimie et biochimie, Université de Moncton, Campus de Moncton, Moncton, NB, E1A 3E9, Canada

    Patrick-Denis St-Coeur & Pier Jr. Morin

  2. Department of Chemistry and Biochemistry, Mount Allison University, Sackville, NB, E4L 1G8, Canada

    Meghan E. Adams, Bryanna J. Kenny, Christopher M. Vogels & Stephen A. Westcott

  3. Department of Chemistry, Saint Mary’s University, Halifax, NS, B3H 3C3, Canada

    Darcie L. Stack & Jason D. Masuda

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  1. Patrick-Denis St-Coeur
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  2. Meghan E. Adams
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  3. Bryanna J. Kenny
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  4. Darcie L. Stack
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  5. Christopher M. Vogels
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  7. Pier Jr. Morin
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  8. Stephen A. Westcott
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Correspondence to Stephen A. Westcott.

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St-Coeur, PD., Adams, M.E., Kenny, B.J. et al. Synthesis and characterization of iminophosphineplatinum(II) complexes of the type (κ2-P,N-2-Ph2PC6H4C(H)=NC6H4X)PtCl2 (X = OMe, F). Transit Met Chem 42, 693–701 (2017). https://doi.org/10.1007/s11243-017-0176-2

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  • DOI: https://doi.org/10.1007/s11243-017-0176-2

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