Skip to main content
SpringerLink
Log in

A vanadium(V) terpyridine complex: synthesis, characterization, cytotoxicity in vitro and induction of apoptosis in cancer cells

  • Published:
Transition Metal Chemistry Aims and scope Submit manuscript

Abstract

A vanadium(V) complex, [VO2(tpy)]ClO4 (1, tpy = 2,2′:6′2″-terpyridine), was synthesized and characterized by physicochemical and spectroscopic methods, as well as by single-crystal and powder X-ray diffraction analysis. Complex 1 has a five-coordinate distorted trigonal bipyramidal geometry. The in vitro cytotoxicity of complex 1 was evaluated against cell lines of liver hepatocellular carcinoma HepG-2, cervical cancer HeLa, lung carcinoma A549, osteoma sarcomatosum HOS, hepatocarcinoma BEL-7402 and normal human hepatic cells LO2 by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assays. The complex displays excellent antitumor activity against the selected cell lines compared with cisplatin and also exhibits lower cytotoxicity toward LO2 cells. Morphological and staining experiments demonstrated that complex 1 induces BEL-7402 cell apoptosis mediated through reactive oxygen species, DNA fragmentation and decrease in mitochondrial membrane potential. In addition, cell cycle distribution investigations showed that complex 1 inhibits cell growth at the G0/G1 phase.

Graphical abstract

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Scheme 1
Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8
Fig. 9

Similar content being viewed by others

References

  1. Pessoa JC, Etcheverry S, Gambino D (2015) Coord Chem Rev 301–301:24–48

    Article  Google Scholar 

  2. Rehder D (2012) Future Med Chem 4:1823–1837

    Article  CAS  Google Scholar 

  3. Narla RK, Dong Y, Klis D, Uckun FM (2001) Clin Cancer Res 7:1094–1101

    CAS  Google Scholar 

  4. Maia PIS, Pavan FR, Leite CQF, Lemos SS, Sousa GF, Batista AA, Nascimento OR, Ellena J, Castellano EE, Niquet E, Deflon VM (2009) Polyhedron 28:398–406

    Article  CAS  Google Scholar 

  5. D’Cruz OJ, Uckun FM (2002) Expert Opin Investig Drugs 11:1829–1836

    Article  Google Scholar 

  6. Evangelou AM (2002) Crit Rev Oncol Hemat 42:249–265

    Article  Google Scholar 

  7. Bishayee A, Waghray A, Patel MA, Chatterjee M (2010) Can Lett 294:1–12

    Article  CAS  Google Scholar 

  8. Banik B, Somyajit K, Hussain A, Nagaraju G, Chakravarty AR (2014) Dalton Trans 43:1321–1331

    Article  CAS  Google Scholar 

  9. Fik MA, Gorczyński A, Kubicki M, Hnatejko Z, Wadas A, Kulesza PJ, Lewińska A, Giel-Pietraszuk M, Wyszko E, Patroniak V (2015) Polyhedron 97:83–93

    Article  CAS  Google Scholar 

  10. Hong XL, Zeng MH, Liu LJ, Ye XL, Yi DS (2017) J Coord Chem 70:1438–1450

    Article  CAS  Google Scholar 

  11. Sheldirck GM (1996) Siemens area detector absorption correction program. Siemens industrial automation Inc, Madison

    Google Scholar 

  12. Sheldrick GM (1997) Germany SHELX 97 (Göttingen University)

  13. Singh NP, Mccoy MT, Tice RR, Schneider EL (1988) Exp Cell Res 175:184–191

    Article  CAS  Google Scholar 

  14. Li W, Han BJ, Yao JH, Jiang GB, Liu YJ (2015) RSC Adv 5:24534–24543

    Article  CAS  Google Scholar 

  15. Deflon VM, Olivera DM, Sousa GF, Batista AA, Dinelli LR, Castellano EE (2002) Z Anorg Allg Chem 628:1140–1144

    Article  CAS  Google Scholar 

  16. Noblía P, Vieites M, Parajón-Costa BS, Baran EJ, Cerecetto H, Draper P, González M, Piro OE, Castellano EE, Azqueta A, Ceráin AL, Monge-Vega A, Gambino D (2005) J Inorg Biochem 99:443–451

    Article  Google Scholar 

  17. Maurya MR, Khan AA, Azam A, Ranjan S, Mondal N, Kumar A, Avecilla F, Pessoa JC (2010) Dalton Trans 39:1345–1360

    Article  CAS  Google Scholar 

  18. Pifferi C, Picchi MP, Cini R (2000) Polyhedron 19:69–76

    Article  CAS  Google Scholar 

  19. Yucesan G, Armatas NG, Zubieta J (2006) Inorg Chim Acta 259:4557–4564

    Article  Google Scholar 

  20. Hagrman PJ, Zubieta J (2000) Inorg Chem 39:3252–3260

    Article  CAS  Google Scholar 

  21. Pidcock A, Richards RE, Venanzi LM (1966) J Chem Soc A 1966:1707–1710

  22. Yuan SC, Ge X (2008) Chin Univ Chem 23:37–42

    CAS  Google Scholar 

  23. Martin FD, Marek J, Alethea L, William L, Benjamin L, Gillian R, Michael W (2008) Dalton Trans 2008:6265–6273

    Google Scholar 

  24. Zhang C, Lai SH, Zeng CC, Tang B, Wan D, Xing DG, Liu YJ (2016) J Biol Inorg Chem 21:1047–1060

    Article  CAS  Google Scholar 

  25. Elmore S (2007) Toxicol Pathol 35:495–516

    Article  CAS  Google Scholar 

  26. Roos WP, Kaina B (2006) Trends Mol Med 12:440–450

    Article  CAS  Google Scholar 

  27. Gunasekarana V, Raj GV, Chand P (2015) J Clin Diag Res 9:GE01–GE05

    Google Scholar 

  28. Azqueta A, Collins AR (2013) Arch Toxicol 87:949–968

    Article  CAS  Google Scholar 

  29. Alapetite C, Wachter T, Sage E, Moustacchi E (1996) Int J Radiat Biol 69:359–369

    Article  CAS  Google Scholar 

  30. Ozawa T (1997) Biosci Rep 17:237–250

    Article  CAS  Google Scholar 

  31. Huang C, Zhang Z, Ding M, Li J, Ye J, Leonard SS, Shen HM, Butterworth L, Lu Y, Costa M, Rojanasakul Y, Castranova V, Vallyathan V, Shi X (2000) J Bio Chem 275:32516–32522

    Article  CAS  Google Scholar 

  32. Cadenas E, Davies KJA (2000) Free Radic Biol Med 29:222–230

    Article  CAS  Google Scholar 

  33. Bagkos G, Koufopoulos K, Piperi C (2014) Med Hypothese 83:175–181

    Article  CAS  Google Scholar 

  34. Goldstein S, Meyerstein D, Czapski G (1993) Radic Biol Med 15:435–445

    Article  CAS  Google Scholar 

  35. Darzynkiewicz Z, Bruno S, Bino GD, Gorczyca W, Hotz MA, Lassota P, Traganos F (1992) Cytom Part A 13:795–808

    Article  CAS  Google Scholar 

Download references

Acknowledgements

This work was financially supported by the Natural Science Foundation of Guangdong Province (Nos. 2014A030307015, 2016A030307048), Featured Innovation in Colleges and Universities of Guangdong Province Project (2014KTSCX169) and Shaoguan University.

Author information

Authors and Affiliations

  1. Department of Chemistry, Shaoguan University, Shaoguan, 512005, Guangdong, People’s Republic of China

    Xian-Lan Hong, Li-Juan Liu, Wen-Guan Lu & Xiao-Bing Wang

Authors
  1. Xian-Lan Hong
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Li-Juan Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Wen-Guan Lu
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Xiao-Bing Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Xian-Lan Hong.

Electronic supplementary material

Below is the link to the electronic supplementary material.

Supplementary material 1 (DOC 75 kb)

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Hong, XL., Liu, LJ., Lu, WG. et al. A vanadium(V) terpyridine complex: synthesis, characterization, cytotoxicity in vitro and induction of apoptosis in cancer cells. Transit Met Chem 42, 459–467 (2017). https://doi.org/10.1007/s11243-017-0150-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11243-017-0150-z

Search

Navigation