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Comparison of nuclease activities of binuclear metal complexes with N6O coordinating heptadentate ligands: [M2L(OAc)2]+ (M = Ni, Mn, L = 2,6-bis(((2-(dimethylamino)ethyl)(pyridin-2-ylmethyl)amino) methyl)-4-methoxyphenol)

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Abstract

Four complexes, [Ni2L(OAc)2](PF6) (1), [Ni2L(OAc)2](BPh4) (2), [Mn2L(OAc)2](PF6) (3) and [Mn2L(OAc)2](BPh4) (4) (L = N,N,N′,N′-2,6-bis(((2-(dimethylamino)ethyl)(pyridin-2-ylmethyl)amino)methyl)-4-methoxyphenol), have been synthesized. Single crystal diffraction reveals that the metal atoms in all four complexes have a distorted octahedral geometry. The interactions of the complexes with calf thymus DNA (CT-DNA) have been investigated by UV absorption, fluorescence spectroscopy, circular dichroism spectroscopy and viscosity measurements, and the most likely mode of CT-DNA binding for these complexes is identified as moderate interaction. Furthermore, the complexes are capable of promoting DNA cleavage through an oxidative pathway, involving hydroxyl radical, singlet oxygen or singlet oxygen-like species.

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Abbreviations

EB:

Ethidium bromide

CT-DNA:

Calf thymus DNA

SOD:

Superoxide dismutase

SC:

Supercoiled

NC:

Nicked circular

MPA:

3-Mercaptopropionic acid

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Authors and Affiliations

  1. Tianjin Institute of Medical and Pharmaceutical Sciences, Tianjin, 300020, People’s Republic of China

    Zun-Wei Tao & Dong-Dong Li

  2. Tianjin Bohai Fine Chemical Co., Ltd, Tianjin, 300270, People’s Republic of China

    Lian-Fu Wang

Authors
  1. Zun-Wei Tao
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  2. Lian-Fu Wang
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  3. Dong-Dong Li
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Correspondence to Zun-Wei Tao or Dong-Dong Li.

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Appendix: Supplementary data

Appendix: Supplementary data

UV absorption spectra, emission spectra and CD spectra.

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Tao, ZW., Wang, LF. & Li, DD. Comparison of nuclease activities of binuclear metal complexes with N6O coordinating heptadentate ligands: [M2L(OAc)2]+ (M = Ni, Mn, L = 2,6-bis(((2-(dimethylamino)ethyl)(pyridin-2-ylmethyl)amino) methyl)-4-methoxyphenol). Transition Met Chem 40, 269–279 (2015). https://doi.org/10.1007/s11243-015-9914-5

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