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Metal-based anticancer agents: targeting androgen-dependent and androgen-independent prostate and COX-positive pancreatic cancer cells by phenanthrenequinone semicarbazone and its metal complexes

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Abstract

A planar, polycyclic and aromatic hydrocarbon ligand, namely 9,10-phenanthrenequinone semicarbazone, and its transition metal complexes have been synthesized and structurally characterized. The in vitro antiproliferative activity of these compounds against five human cancer cell lines revealed that they were effective against androgen receptor-positive/negative prostate cancer cells as well as COX-positive pancreatic BxPC-3 cancer cell line. The driving force behind such antiproliferative activity seems to be the up-regulated COX expression in these cells, which was amenable for targeting through metal complexation. These structural motifs can, therefore, serve as a starting point for developing novel cytotoxic agents against the growing number of prostate and pancreatic cancers.

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Acknowledgments

S.P. and A.V. are thankful to Mr. P. A. Inamdar and Dr. E. M. Khan for their keen interest and encouragement.

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Authors and Affiliations

  1. Department of Life and Physical Sciences, Lincoln University, 252 Founders Hall, 820 Chestnut St., Jefferson City, MO, 65101, USA

    Zahra Afrasiabi & Rosana Almudhafar

  2. Department of Chemistry, Western Michigan University, Kalamazoo, MI, USA

    Di Xiao & Ekkehard Sinn

  3. Department of Chemistry, Missouri University of Science and Technology, Rolla, MO, 65409, USA

    Amitava Choudhury

  4. Karmanos Cancer Research Institute, Wayne State University, Detroit, MI, USA

    Aamir Ahmad, Fazlul Sarkar & Subhash Padhye

  5. ISTRA, Department of Chemistry, Abeda Inamdar Senior College, University of Pune, Pune, 411001, India

    Alok Vyas & Subhash Padhye

Authors
  1. Zahra Afrasiabi
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  2. Rosana Almudhafar
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Correspondence to Zahra Afrasiabi or Subhash Padhye.

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Afrasiabi, Z., Almudhafar, R., Xiao, D. et al. Metal-based anticancer agents: targeting androgen-dependent and androgen-independent prostate and COX-positive pancreatic cancer cells by phenanthrenequinone semicarbazone and its metal complexes. Transition Met Chem 38, 665–673 (2013). https://doi.org/10.1007/s11243-013-9735-3

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  • DOI: https://doi.org/10.1007/s11243-013-9735-3

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