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Synthesis, crystal structures and anticancer activities of two decavanadate compounds

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Abstract

Two ammonium decavanadate(V) compounds, (H2tmen)3V10O28·6H2O (1) and (H2en)3V10O28·2H2O (2), where H2tmen and H2en represent the doubly protonated N,N,N′,N′-tetramethylethylenediammonium ion and doubly protonated ethylenediammonium ion, respectively, have been synthesized and structurally characterized by elemental analyses, spectroscopic (i.r., e.s.r.) studies, and single-crystal X-ray diffraction. Both crystal structures reveal the presence of the [V10O28]6− cluster anions, doubly protonated diammonium cations, and lattice water molecules. Hydrogen bonds assemble these two compounds to form three-dimensional networks. The in vitro anticancer activity against A549 and P388 tumor cells lines has also been determined by the MTT-based assay, and the results suggest that both compounds can inhibit proliferation of these two kinds of tumor cells.

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Acknowledgments

This project was supported by the Natural Science Foundation of Qingdao City (No. 09-1-3-73-jch) and the Ph.D. Program Foundation of Ministry of Education of China.

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Authors and Affiliations

  1. Marine Drug & Food Institute, Ocean University of China, 5 Yushan Road, 266003, Qingdao, People’s Republic of China

    Yan-Tuan Li & Chun-Yuan Zhu

  2. Key Lab. Marine Drug, Chinese Minist. Educ., Ocean University of China, Qingdao, People’s Republic of China

    Zhi-Yong Wu & Man Jiang

  3. College of Marine Life Science, Ocean University of China, 266003, Qingdao, People’s Republic of China

    Cui-Wei Yan

Authors
  1. Yan-Tuan Li
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  2. Chun-Yuan Zhu
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  3. Zhi-Yong Wu
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  4. Man Jiang
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  5. Cui-Wei Yan
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Correspondence to Yan-Tuan Li or Cui-Wei Yan.

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Li, YT., Zhu, CY., Wu, ZY. et al. Synthesis, crystal structures and anticancer activities of two decavanadate compounds. Transition Met Chem 35, 597–603 (2010). https://doi.org/10.1007/s11243-010-9369-7

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  • DOI: https://doi.org/10.1007/s11243-010-9369-7

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