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Synthesis and antibacterial activity of copper(II) complexes with sulphathiazole and cephalosporin ligands

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Abstract

Copper(II) reacts with cephalosporins plus sulphathiazole (Hstz) to form the following mixed complexes: [Cu(cefazol)(stz)(H2O)], [Cu(cephalot)(stz)(H2O)2], [Cu(cefotax)(stz)], [Cu(ceftria)(Hstz)] and [Cu(cefepime)(stz)Cl] (Hcefazol = cefazolin, Hcephalot = cephalothin, Hcefotax = cefotaxime and H2ceftria = ceftriaxone) which were characterized by physicochemical and spectroscopic methods. The spectra indicated that most of the cephalosporins are probably acting as monoanionic multidentate chelating agents, the exception being ceftriaxone which is dianionic. The complexes are insoluble in water and common organic solvents and probably have polymeric structures. They have been screened for activity against several bacteria, and the results are compared with the activity of cephalosporins.

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Acknowledgements

Authors are grateful to the Comisión de Investigación at the Universidad de Oriente for providing financial support. Authors are also grateful to Lic. Erasto Bastardo for the elemental analyses.

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Authors and Affiliations

  1. Departamento de Química, Universidad de Oriente, Apartado Postal 208, Cumana, Venezuela

    Juan R. Anacona & Ivor Osorio

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  1. Juan R. Anacona
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  2. Ivor Osorio
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Correspondence to Juan R. Anacona.

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Anacona, J.R., Osorio, I. Synthesis and antibacterial activity of copper(II) complexes with sulphathiazole and cephalosporin ligands. Transition Met Chem 33, 517–521 (2008). https://doi.org/10.1007/s11243-008-9074-y

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  • DOI: https://doi.org/10.1007/s11243-008-9074-y

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