Abstract
Cefoxitin (Hcefoxi) interacts with transition metal ions to give [M(cefoxi)Cl] complexes [M=Fe(III), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II)] which were characterized by physicochemical and spectroscopic methods. A tetrahedral geometry is suggested for their structure, where the cefoxitin behaves as a monoanionic tridentate ligand. The complexes have been screened for antibacterial activity against several bacteria, and the results show that they are less active than the parent cefoxitin.
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Anacona, J.R., Gil, C.C. Synthesis and antibacterial activity of cefoxitin metal complexes. Transition Met Chem 30, 605–609 (2005). https://doi.org/10.1007/s11243-005-3847-3
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DOI: https://doi.org/10.1007/s11243-005-3847-3