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Template synthesis and physicochemical studies of 14-membered hexaazmacrocyclic complexes with Co(II), Ni(II), Cu(II) and Zn(II): a comparative spectroscopic approach on DNA binding with Cu(II) and Ni(II) complexes

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Abstract

A new series of 14-membered pendant arm hexaazamacrocyclic complexes of the type [MLX2] · [M = Co(II), Ni(II), Cu(II) or Zn(II) for X = Cl; Co(II), Ni(II), Cu(II) or Zn(II) for X = NO3] has been synthesized by metal template condensation of 1,2-phenylenediamine and 1,4-phenylenediamine with formaldehyde in methanol. The mode of bonding and overall geometry of these complexes have been deduced by elemental analyses, molar conductance values, FT-IR, 1H-NMR, 13C-NMR, EPR, ESI-mass and UV–VIS along with magnetic measurement studies. The fluorescence and UV–VIS studies revealed a significant binding ability to DNA.

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Acknowledgements

The Chairman, Department of Chemistry, Aligarh Muslim University, Aligarh, India, is acknowledged for providing necessary research facilities. The authors thank Regional Sophisticated Instrumentation Center, Indian Institute of Technology, Bombay, for recording the EPR spectra and CDRI Lucknow, India, for providing 1H-NMR, 13C-NMR, ESI-mass spectral and analytical data for the compounds.

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Authors and Affiliations

  1. Division of Inorganic Chemistry, Department of Chemistry, Aligarh Muslim University, Aligarh, India

    Farha Firdaus, Kaneez Fatma, Mohammad Azam & Mohammad Shakir

  2. Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh, 202002, India

    Shahper N. Khan & Asad U. Khan

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  1. Farha Firdaus
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  2. Kaneez Fatma
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  3. Mohammad Azam
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Correspondence to Farha Firdaus.

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Firdaus, F., Fatma, K., Azam, M. et al. Template synthesis and physicochemical studies of 14-membered hexaazmacrocyclic complexes with Co(II), Ni(II), Cu(II) and Zn(II): a comparative spectroscopic approach on DNA binding with Cu(II) and Ni(II) complexes. Transition Met Chem 33, 467–473 (2008). https://doi.org/10.1007/s11243-008-9066-y

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