Skip to main content
SpringerLink
Log in

Ruthenium(II) complexes containing 2,9-dimethyl-1,10-phenanthroline and 4,4′-dimethyl-2,2′-bipyridine as ancillary ligands: synthesis, characterization and DNA-binding

  • Published:
Transition Metal Chemistry Aims and scope Submit manuscript

Abstract

Two new Ruthenium (II) polypyridyl complexes [Ru(dmp)2(ipbp)](ClO4)2 (1) (dmp = 2,9-dimethyl-1,10-phenanthroline, ipbp = 3-(1H-imidazo[4,5-f][1,10]phenanthrolin-2-yl)-4H-1-banzopyran-2-one) and [Ru(dmb)2(ipbp)](ClO4)2 (2) (dmb = 4,4′-dimethyl-2,2′-bipyridine) have been synthesized and characterized by elemental analysis, FAB-MS, ES-MS and 1H NMR and cyclic voltammetric methods. The DNA-binding behaviors of these complexes were investigated by spectroscopic titration, viscosity measurements, and thermal denaturation. Absorption titration and thermal denaturation studies reveal that these complexes are moderately strong binders of calf thymus DNA (CT-DNA). Viscosity measurements show that the complexes 1 and 2 interact with CT-DNA by intercalative mode. The DNA-binding affinity of the complex 2 is larger than that of complex 1.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Scheme 1
Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5

Similar content being viewed by others

References

  1. Erkkila KE, Odom DT, Barton JK (1999) Chem Rev 99:2777

    Article  CAS  Google Scholar 

  2. Ji LN, Zou XH, Liu JG (2001) Coord Chem Rev 216–217:513

    Article  Google Scholar 

  3. Xiong Y, Ji LN (1999) Coord Chem Rev 216–217:711

    Article  Google Scholar 

  4. Grimm GN, Boutorine AS, Lincoln P, Nordén B, Helene C (2002) Chem Biochem 3:324

    CAS  Google Scholar 

  5. Antonini I, Polucci P, Magnano A, Barbara G, Palumbo M, Menta E, Pescalli N (2002) J Med Chem 45:697

    Article  CAS  Google Scholar 

  6. Nordén B, Lincoln P, Akerman B, Tuite E (1986) Met Ions Biol Syst 33:178

    Google Scholar 

  7. Pyle A, Barton JK (1990) Prog Inorg Chem 38:413

    Article  CAS  Google Scholar 

  8. Sigman DS, Mazumder A, Perrin DM (1993) Chem Rev 93:2295

    Article  CAS  Google Scholar 

  9. Sundquist WI, Lippard SJ (1990) Coord Chem Rev 100:293

    Article  CAS  Google Scholar 

  10. Coe BJ, Friessen DA, Thompson DW, Meyer TJ (1996) Inorg Chem 35:4575

    Article  CAS  Google Scholar 

  11. Lawrance GA (1985) Polyhedron 4:817

    Article  CAS  Google Scholar 

  12. Satyanannrayana S, Dabrowiak JC, Chaires JB (1993) Biochemistry 32:2573

    Article  Google Scholar 

  13. Coury JE, Anderson JR, McFail-Isom L, Williams LD, Bottomley A (1997) J Am Chem Soc 119:3792

    Article  CAS  Google Scholar 

  14. Friedman AE, Chambron JC, Sauvage JP, Turro NJ, Barton JK (1990) J Am Chem Soc 112:4960

    Article  CAS  Google Scholar 

  15. Friedman AE, Kumar CV, Turro NJ, Barton JK (1991) Nucleic Acids Res 19:2595

    Article  CAS  Google Scholar 

  16. Jenkins Y, Friedman AE, Turro NJ, Barton JK (1992) Biochemistry 31:10809

    Article  CAS  Google Scholar 

  17. Turro C, Bossmann SH, Jenkins Y, Barton JK, Turro NJ (1995) J Am Chem Soc 117:9026

    Article  CAS  Google Scholar 

  18. Hirot C, Lincoln P, Nordén B (1993) J Am Chem Soc 115:3448

    Article  Google Scholar 

  19. Eriksson M, Leijon M, Hirot C, Nordén B, Graslund A (1994) Biochemistry 33:5031

    Article  CAS  Google Scholar 

  20. Haq I, Lincoln P, Suh D, Nordén B, Chowdhry BZ, Chaires JB (1995) J Am Chem Soc 117:4788

    Article  CAS  Google Scholar 

  21. Lincoln P, Broo A, Nordén B (1996) J Am Chem Soc 118:2644

    Article  CAS  Google Scholar 

  22. Tuite E, Lincoln P, Nordén B (1997) J Am Chem Soc 117:239

    Article  Google Scholar 

  23. Coates CG, Jacquet L, McGavey JJ, Bell SEJ, Al-Obaidi AHR, Kelly JM (1997) J Am Chem Soc 119:7103

    Article  Google Scholar 

  24. Chaires JB (1998) Biopolymer (Nucl Acid Sci) 44:201

    Article  Google Scholar 

  25. Pyle AM, Rehman JP, Meshoyrer R, Kumar CV, Turro NJ, Barton JK (1989) J Am Chem Soc 111:3051

    Article  CAS  Google Scholar 

  26. Naing K, Takahashi M, Taniguchi M, Yamagishi A (1994) Bull Chem Soc Jpn 67:2424

    Article  CAS  Google Scholar 

  27. Marmur J (1961) J Mol Biol 3:208

    Article  CAS  Google Scholar 

  28. Reichmann MF, Rice SA, Thomas CA, Doty P (1954) J Am Chem Soc 76:3047

    Article  CAS  Google Scholar 

  29. Collin JP, Sauvage TP (1986) Inorg Chem 25:135

    Article  CAS  Google Scholar 

  30. Sullivan BP, Salmon DJ, Meyer TJ (1978) Inorg Chem 17:3334

    Article  CAS  Google Scholar 

  31. Liu YJ, Chao H, Yao JH, Li H, Yuan YX, Ji LN (2004) Helv Chim Acta 87:3119

    Article  CAS  Google Scholar 

  32. AWolf, Shimer Jr GH, Meehan T (1987) Biochemistry 26:6392

    Article  Google Scholar 

  33. Lakowicz JR, Webber G (1973) Biochemistry 12:4161

    Article  CAS  Google Scholar 

  34. Chaires JB, Dattagupta N, Crothers DM (1982) Biochemistry 21:3933

    Article  CAS  Google Scholar 

  35. Cohen G, Eisenberg H (1968) Biopolymers 8:45

    Article  Google Scholar 

  36. Lincoln P, Nordén B (1998) J Phys Chem B 102:9583

    Article  CAS  Google Scholar 

  37. Liu JG, Zhang QL, Shi XF, Ji LN (2001) Inorg Chem 40:5045

    Article  CAS  Google Scholar 

  38. Kumar CV, Asuncion EH (1993) J Am Chem Soc 115:8547

    Article  CAS  Google Scholar 

  39. Satyanarayana S, Dabroniak JC, Chaires JB (1992) Biochemistry 31:9319

    Article  CAS  Google Scholar 

  40. Kelly JM, Tossi AB, McConnell DJ, OhUigin C (1985) Nucleic Acids Res 13:6017

    Article  CAS  Google Scholar 

  41. Neyhart GA, Grover N, Smith SR, Kalsbeck WA, Fairly TA, Cory M, Thorp HH (1993) J Am Chem Soc 115:4423

    Article  CAS  Google Scholar 

Download references

Acknowledgments

We are grateful to the Nature Science Foundation of Guangdong Province (No 0711220400121) and Guangdong Pharmaceutical University for financial support.

Author information

Authors and Affiliations

  1. School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, 510006, P.R. China

    Yun-Jun Liu, Xiao-Yan Guan, Xin-Yu Wei, Li-Xin He & Wen-Jie Mei

  2. Instrumentation Analysis and Research Center, Sun Yat-Sen University, Guangzhou, 510275, P.R. China

    Jun-Hua Yao

Authors
  1. Yun-Jun Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Xiao-Yan Guan
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Xin-Yu Wei
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Li-Xin He
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Wen-Jie Mei
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Jun-Hua Yao
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Yun-Jun Liu.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Liu, YJ., Guan, XY., Wei, XY. et al. Ruthenium(II) complexes containing 2,9-dimethyl-1,10-phenanthroline and 4,4′-dimethyl-2,2′-bipyridine as ancillary ligands: synthesis, characterization and DNA-binding. Transition Met Chem 33, 289–294 (2008). https://doi.org/10.1007/s11243-007-9042-y

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11243-007-9042-y

Keywords

Search

Navigation