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Stopped-flow study of H+ induced CO2 release from a non-peptide analogue of decarboxylase-substrate mimicking cis-[Cr(C2O4)(AaraNH2)(O2CO)]−

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Abstract

A stopped-flow method was used to investigate the kinetics of the acid hydrolysis of a newly synthesised coordination ion of the cis-[Cr(C2O4)(AaraNH2)(O2CO)]− type, where AaraNH2 stands for methyl 3-amino-2,3-dideoxy-α -d-arabino-hexapyranoside, over a range of hydrogen ion concentrations 0.01 < [H+] < 2.7 M and temperatures 5 < T < 25°C. Initiated by perchloric acid (HClO4), the hydrolysis (decarboxylation) of the chromium(III) ion complexed with a bicoordinately linked carbonate ligand turned out to be a two-step process. The kinetic parameters k 1, k 2 were determined of both steps of the hydrolysis of the cis-[Cr(C2O4)(AaraNH2)(O2CO)]− ion, as was the equilibrium constant K of the protonation of this ion, which precedes the actual two-step hydrolysis. From an analysis of the values of the constants obtained, a mechanism is proposed for the acid hydrolysis of the cis-[Cr(C2O4)(AaraNH2)(O2CO)]− coordination ion.

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Authors and Affiliations

  1. Department of General Chemistry, University of Gdańsk, Sobieskiego 18/19, 80-952, Gdańsk, Poland

    Dagmara Jacewicz, Agnieszka Łapińska, Aleksandra Dąbrowska & Lech Chmurzyński

  2. Department of Medical Chemistry, Medical University of Gdańsk, Dębinki 1, 80-211, Gdańsk, Poland

    Michał Woźniak

Authors
  1. Dagmara Jacewicz
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  2. Agnieszka Łapińska
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  3. Aleksandra Dąbrowska
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  4. Lech Chmurzyński
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  5. Michał Woźniak
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Correspondence to Lech Chmurzyński.

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Jacewicz, D., Łapińska, A., Dąbrowska, A. et al. Stopped-flow study of H+ induced CO2 release from a non-peptide analogue of decarboxylase-substrate mimicking cis-[Cr(C2O4)(AaraNH2)(O2CO)]− . Transition Met Chem 31, 1045–1051 (2006). https://doi.org/10.1007/s11243-006-0107-0

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