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Template synthesis, spectroscopic studies and biological screening of macrocyclic complexes derived from thiocarbohydrazide and benzil

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Abstract

A novel series of complexes of the type [M(TML)X2]; where TML is a tetradentate macrocyclic ligand; M = Co(II), Ni(II), Cu(II) or Zn(II); X = Cl−, CH3COO− or NO −3 have been synthesized by template condensation of benzil and thiocarbohydrazide in the presence of divalent metal salts in methanolic medium. The complexes have been characterized with the help of elemental analyses, conductance measurements, molecular weight determination, magnetic measurements, electronic, NMR, infrared and far infrared spectral studies. Electronic spectra along with magnetic moments suggest the six coordinate octahedral geometry for these complexes. The low value of molar conductance indicates them to be non-electrolytes. The biological activities of metal complexes have been tested in vitro against a number of pathogenic bacteria to assess their inhibiting potential.

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Authors and Affiliations

  1. Department of Chemistry, National Institute of Technology, Kurukshetra, 136 119, India

    Dharam P. Singh & Ramesh Kumar

  2. Serum Institute of India Ltd., 212/2, Hadapsar, Pune, 411 028, India

    Parikshit Tyagi

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  1. Dharam P. Singh
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  2. Ramesh Kumar
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  3. Parikshit Tyagi
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Correspondence to Dharam P. Singh.

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Singh, D.P., Kumar, R. & Tyagi, P. Template synthesis, spectroscopic studies and biological screening of macrocyclic complexes derived from thiocarbohydrazide and benzil. Transition Met Chem 31, 970–973 (2006). https://doi.org/10.1007/s11243-006-0096-z

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  • DOI: https://doi.org/10.1007/s11243-006-0096-z

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