Skip to main content

Advertisement

Log in

Myocardial infarction due to late stent thrombosis following epileptic convulsive seizures

  • Published:
Journal of Thrombosis and Thrombolysis Aims and scope Submit manuscript

Abstract

We report the first case in the literature of acute myocardial infarction due to very late (5 years) drug-eluting stent (DES) thrombosis presenting with inferior ST-elevation myocardial infarction immediately after epileptic convulsive seizures in a patient with known coronary artery disease. A bare-metal stent had been implanted in the left anterior descending coronary artery in 2002, and a drug-eluting stent implanted in the right coronary artery in 2003. We discuss the possible pathogenetic mechanisms implied in convulsive epileptic crisis resulting in development of very late DES thrombosis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Chin PS, Branch KR, Becker KJ (2004) Myocardial infarction following brief convulsive seizures. Neurology 63:2453–2454

    PubMed  Google Scholar 

  2. Kono T, Morita H, Kuroiwa T, Onaka H, Takatsuka H, Fujiwara A (1994) Left ventricular wall motion abnormalities in patients with subarachnoid hemorraghe: neuronic stunned myocardium. J Am Coll Cardiol 24:636–640

    Article  CAS  PubMed  Google Scholar 

  3. Chuang CP, Chao CL (2000) Neurogenic stunned myocardium in a patient with metastatic brain tumors. Int J Cardiol 76:251–253

    Article  CAS  PubMed  Google Scholar 

  4. Chin PS, Branch KR, Becker KJ (2005) Postictal neurogenic stunned myocardium. Neurology 64:1977–1978

    Article  PubMed  Google Scholar 

  5. Samuels MA (2007) The brain–heart connection. Circulation 116:77–84

    Article  PubMed  Google Scholar 

  6. Simon RP, Aminoff MJ, Benowitz NL (1984) Changes in plasma catecholamines after tonic-clonic seizures. Neurology 34:255–257

    CAS  PubMed  Google Scholar 

  7. Tigaran S, Mølgaard H, McClelland R, Dam M, Jaffe AS (2003) Evidence of cardiac ischemia during seizures in drug refractory epilepsy patients. Neurology 60:492–495

    CAS  PubMed  Google Scholar 

  8. Shimizu M, Kagawa A, Takano T, Masai H, Miwa Y (2008) Neurogenic stunned myocardium associated with status epilepticus and postictal catecholamine surge. Intern Med 47:269–273

    Article  PubMed  Google Scholar 

  9. Sakuragi S, Tokunaga N, Okawa K, Kakishita M, Ohe T (2007) A case of Takotsubo cardiomyopathy associated with epileptic seizure: reversible left ventricular wall motion abnormality and ST-segment elevation. Heart Vessels 22:59–63

    Article  PubMed  Google Scholar 

  10. Tsuchihashi K, Ueshima K, Uchida T, Oh-mura N, Kimura K, Owa M, Yoshiyama M, Miyazaki S, Haze K, Ogawa H, Honda T, Hase M, Kai R, Morii I, Angina Pectoris-Myocardial Infarction Investigations in Japan (2001) Transient left ventricular apical ballooning without coronary artery stenosis: a novel heart syndrome mimicking acute myocardial infarction. Angina Pectoris-Myocardial Infarction Investigations in Japan. J Am Coll Cardiol 38:11–18

    Article  CAS  PubMed  Google Scholar 

  11. Gianni M, Dentali F, Grandi AM, Sumner G, Hiralal R, Lonn E (2006) Apical ballooning syndrome or Takotsubo cardiomyopathy: a systematic review. Eur Heart J 27:1523–1529

    Article  PubMed  Google Scholar 

  12. Ghilotti M, Lova P, Balduini C, Torti M (2007) Epinephrine induces intracellular Ca2+ mobilization in thrombin-desensitized platelets: a role for GPIb-IX-V. Platelets 18:135–142

    Article  CAS  PubMed  Google Scholar 

  13. Grenegård M, Vretenbrant-Őberg K, Nylander M, Desilets S, Lindstrom EG, Larsson A, Ramström I, Ramström S, Lindahl TL (2008) The ATP-gated P2X1 receptor plays a pivotal role in activation of aspirin-treated platelets by thrombin and epinephrine. J Biol Chem 283:18493–18504

    Article  PubMed  CAS  Google Scholar 

  14. Spaulding C, Daemen J, Boersma E, Cutlip DE, Serruys PW (2007) A pooled analysis of data comparing sirolimus-eluting stents with bare-metal stents. N Engl J Med 356:989–997

    Article  CAS  PubMed  Google Scholar 

  15. Mauri L, Hsieh WH, Massaro JM, Ho KK, D’Agostino R, Cutlip DE (2007) Stent thrombosis in randomized clinical trials of drug-eluting stents. N Engl J Med 356:1020–1029

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Roberto Bonmassari.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bonmassari, R., Zeni, P., Spadaro, R. et al. Myocardial infarction due to late stent thrombosis following epileptic convulsive seizures. J Thromb Thrombolysis 29, 512–515 (2010). https://doi.org/10.1007/s11239-009-0380-9

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11239-009-0380-9

Keywords

Navigation