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Interaction of angiotensin-converting enzyme and apolipoprotein E gene polymorphisms in ischemic stroke involving large-vessel disease

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Abstract

A relationship between apolipoprotein E (Apo E) genotype and angiotensin-converting enzyme (ACE) insertion-deletion (Ins-Del) mutation and stroke was suggested. We investigated the association of Apo E4 and ACE Ins/Del genotypes with stroke risk and changes in serum lipids in 228 consecutive Tunisian stroke patients, and 323 age-and gender-matched controls. Comparable frequencies of ACE Ins/Del alleles were seen between patients and controls. The prevalence of Apo ε3 allele and Apo E3/E3 were lower (P < 0.001), while the frequency of Apo ε4 allele and ε4-containing genotypes (E3/E4 and E4/E4) were elevated (P < 0.001) among patients. Higher proportion of Apo E4-carrying + ACE Del/Del positive cases were seen in young (<50 years) patients (P = 0.012), and was associated with large vessel stroke (P = 0.035). Mean serum cholesterol, LDL, HDL, and triglycerides were comparable between E4-containing and no E4-containing and ACE Del/Del-positive patients. Apo E4 and ACE Del/Del genotype combination substantially increase stroke risk, supporting the notion that interactions of multiple gene variants influence stroke pathogenesis.

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Authors and Affiliations

  1. Research Unit of Hematological and Autoimmune Diseases, Faculty of Pharmacy, University of Monastir, Monastir, Tunisia

    Sarra Saidi, Walid Zammiti & Touhami Mahjoub

  2. Department of Neurology, CHU Sahloul, Sousse, Tunisia

    Lamia B. Slamia & Sofyan B. Ammou

  3. Department of Medical Biochemistry, College of Medicine & Medical Sciences, Arabian Gulf University, 22979, Manama, Bahrain

    Wassim Y. Almawi

Authors
  1. Sarra Saidi
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  2. Walid Zammiti
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  3. Lamia B. Slamia
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  4. Sofyan B. Ammou
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  5. Wassim Y. Almawi
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  6. Touhami Mahjoub
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Correspondence to Wassim Y. Almawi.

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Saidi, S., Zammiti, W., Slamia, L.B. et al. Interaction of angiotensin-converting enzyme and apolipoprotein E gene polymorphisms in ischemic stroke involving large-vessel disease. J Thromb Thrombolysis 27, 68–74 (2009). https://doi.org/10.1007/s11239-007-0165-y

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  • DOI: https://doi.org/10.1007/s11239-007-0165-y

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