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Synthesis, crystal structure and fungicidal activity of 1-(4-chlorophenyl)-2-(5-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)-4-phenyl-4H-1,2,4-triazol-3-ylthio)ethanone

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Abstract

A novel bis-heterocyclic compound was synthesized and characterized. The crystal structure of the title compound (C22H20ClN5OS, Mr = 437.94) has been determined by single-crystal X-ray diffraction. The crystal is of triclinic, space group P-1 with a = 8.646 (2), b = 9.148 (3), c = 14.540 (4) Å, α = 94.422 (4), β = 98.500 (4), γ = 102.823 (4)°, V = 1101.8 (5) Å3, Z = 2, F(000) = 312, Dc = 1.320 g/cm3, μ = 0.2900 mm−1, the final R 1 = 0.041000 and wR 2 = 0.1160 for 2675 observed reflections with I > 2σ(I). A total of 5623 reflections were collected, of which 3866 were independent (R int = 0.019000). The fungicidal activity of title compound was determined, the results showed the title compound displayed moderate fungicidal activity against G. zeae Petch, Phytophthora infestans (Mont.) de Bary, Botryosphaeria berengeriana f. sp. piricola (Nose) koganezawa et Sakuma, Fusarium oxysporum f.sp. cucumerinum, and Cercospora arachidicola.

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Authors and Affiliations

  1. School of Medicine, Jinhua College of Profession and Technology, Zhejiang, 321017, China

    Xiao-Dong Yang

  2. Normal College, Jinhua College of Profession and Technology, Zhejiang, 321017, China

    Yu-Ye Yu

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  1. Xiao-Dong Yang
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  2. Yu-Ye Yu
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Correspondence to Xiao-Dong Yang.

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Yang, XD., Yu, YY. Synthesis, crystal structure and fungicidal activity of 1-(4-chlorophenyl)-2-(5-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)-4-phenyl-4H-1,2,4-triazol-3-ylthio)ethanone. Struct Chem 19, 693–696 (2008). https://doi.org/10.1007/s11224-008-9362-3

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  • DOI: https://doi.org/10.1007/s11224-008-9362-3

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