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Polymorphic Gene Markers of Lipid Metabolism Are Associated with Diabetic Nephropathy in Patients with Type 1 Diabetes Mellitus

  • Human Genetics
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Abstract

In groups of type 1 diabetes mellitus patients with and without clinical signs of diabetic nephropathy (n = 62 and 68, respectively), a search was made for associations between diabetic nephropathy and the polymorphic marker ε2/ε3/ε4 of apolipoprotein E gene (APOE), I/D marker of apolipoprotein B gene (APOB), and Ser447Ter marker of lipoprotein lipase-encoding gene (LPL). The risk of diabetic nephropathy was higher in the carriers of allele ε3 and genotype ε3/ε3 of the polymorphic marker ε2/ε 3/ε4 of APOE gene as well as in the carriers of allele I and APOB genotype I/I gene (OR = 2.08 and 2.16; 1.91 and 2.11, respectively). Conversely, the carriers of allele D showed a reduced risk of this complication (OR = 0.52). No significant differences in distribution of alleles and genotypes of the polymorphic marker Ser447Ter of LPL gene were found between the groups. Our results indicate that the genes encoding two major components of lipid metabolism are involved in the development of diabetic nephropathy in patients with type 1 diabetes mellitus.

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Authors and Affiliations

  1. State Research Institute of Genetics and Selection of Industrial Microorganisms, Moscow, 117545, Russia

    N. Yu. Yakunina, O. E. Voron’ko, K. V. Savost’yanov & V. V. Nosikov

  2. Endocrinological Research Center, Russian Academy of Medical Sciences, Moscow, 117036, Russia

    M. V. Shestakova, O. K. Vikulova, L. A. Chugunova, M. Sh. Shamkhalova & I. I. Dedov

Authors
  1. N. Yu. Yakunina
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  2. M. V. Shestakova
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  3. O. E. Voron’ko
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  4. O. K. Vikulova
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  5. K. V. Savost’yanov
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  6. L. A. Chugunova
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  7. M. Sh. Shamkhalova
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  8. I. I. Dedov
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  9. V. V. Nosikov
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Translated from Genetika, Vol. 41, No. 7, 2005, pp. 931–937.

Original Russian Text Copyright © 2005 by Yakunina, Shestakova, Voron’ko, Vikulova, Savost’yanov, Chugunova, Shamkhalova, Dedov, Nosikov.

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Yakunina, N.Y., Shestakova, M.V., Voron’ko, O.E. et al. Polymorphic Gene Markers of Lipid Metabolism Are Associated with Diabetic Nephropathy in Patients with Type 1 Diabetes Mellitus. Russ J Genet 41, 760–765 (2005). https://doi.org/10.1007/s11177-005-0157-y

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  • DOI: https://doi.org/10.1007/s11177-005-0157-y

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