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Synthesis of 3(5)-Amino-4-acylamino-5(3)-arylsulfanylpyrazoles and Their Fused Derivatives on the Basis of N-(2,2,2-Trichloro-1-hydroxyethyl)benzamides

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Abstract

Addition products of carboxylic acid amides and trichloroacetaldehyde are readily converted into 3-arylsulfanyl-2-acylamino-3-chloroacrylonitriles which react with hydrazine hydrate to afford 3(5)-amino-5(3)-arylsulfanyl-4-acylaminopyrazoles. The presence of an amidine fragment in the latter makes them capable of undergoing cyclocondensations with β-dicarbonyl compounds and ethyl cyanoacetate.

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Authors and Affiliations

  1. Institute of Bioorganic and Petroleum Chemistry, National Academy of Sciences of Ukraine, Kiev, Ukraine

    S. V. Popil'nichenko, S. G. Pil'o, B. S. Brovarets & B. S. Drach

  2. Institute of Organic Chemistry, National Academy of Sciences of Ukraine, Kiev, Ukraine

    A. N. Chernega

Authors
  1. S. V. Popil'nichenko
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  2. S. G. Pil'o
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  3. B. S. Brovarets
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  4. A. N. Chernega
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  5. B. S. Drach
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Translated from Zhurnal Obshchei Khimii, Vol. 75, No. 11, 2005, pp. 1902–1906.

Original Russian Text Copyright © 2005 by Popil'nichenko, Pil'o, Brovarets, Chernega, Drach.

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Popil'nichenko, S.V., Pil'o, S.G., Brovarets, B.S. et al. Synthesis of 3(5)-Amino-4-acylamino-5(3)-arylsulfanylpyrazoles and Their Fused Derivatives on the Basis of N-(2,2,2-Trichloro-1-hydroxyethyl)benzamides. Russ J Gen Chem 75, 1816–1820 (2005). https://doi.org/10.1007/s11176-005-0517-2

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  • DOI: https://doi.org/10.1007/s11176-005-0517-2

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