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Synthesis of 3(5)-aryl-5(3)-pyrazolyl-1,2,4-oxadiazole nitro derivatives

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Chemistry of Heterocyclic Compounds Aims and scope

A method was developed for the synthesis of 3(5)-aryl-5(3)-pyrazolyl-1,2,4-oxadiazoles by acylation of amidoximes with acyl chlorides, followed by cyclization of pyrazolyl-O-acylamidoximes into the respective oxadiazoles. Nitration of these products was studied, in combination with nucleophilic substitution reactions in the obtained nitro derivatives.

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The authors would like to express their gratitude to the Scientific Schools Development Program at the N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences.

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Authors and Affiliations

  1. N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Ave, Moscow, 119991, Russia

    Tatyana K. Shkineva, Irina A. Vatsadze, Tigran E. Khoranyan, Dmitry L. Lipilin & Igor L. Dalinger

  2. N. N. Semenov Federal Research Center of Chemical Physics, Russian Academy of Sciences, 4 Kosygina St, Moscow, 119991, Russia

    Alla N. Pivkina

Authors
  1. Tatyana K. Shkineva
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  2. Irina A. Vatsadze
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  3. Tigran E. Khoranyan
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  4. Dmitry L. Lipilin
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  5. Alla N. Pivkina
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  6. Igor L. Dalinger
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Correspondence to Igor L. Dalinger.

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Translated from Khimiya Geterotsiklicheskikh Soedinenii, 2021, 57(7/8), 828–836

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Shkineva, T.K., Vatsadze, I.A., Khoranyan, T.E. et al. Synthesis of 3(5)-aryl-5(3)-pyrazolyl-1,2,4-oxadiazole nitro derivatives. Chem Heterocycl Comp 57, 828–836 (2021). https://doi.org/10.1007/s10593-021-02987-3

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  • DOI: https://doi.org/10.1007/s10593-021-02987-3

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