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Formulation of Technetium-99m Labeled Antimony Trisulfide Colloid, Intended for Sentinel Lymph Node Imaging, Using New Techniques

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Abstract

99mTc-Antimony trisulfide colloid is a radiopharmaceutical that can be useful in evaluation of patients with breast cancer. The current preparation method requires prolonged boiling on a water bath, and the recommended quality control procedure is cumbersome and time-consuming. With a microwave oven, the heating time necessary to provide the maximal labeling efficiency is reduced to 15 s. A new mini-paper chromatography (MPC) system has been developed to analyze the radiochemical purity (RCP) of the labeled preparation involving two different developing solvents. The recommended thin-layer chromatography (TLC) system involving the use of an Al2O3-coated plate requires an average time for drying and development of 38.4 × 0.21 min (n = 30) to complete, whereas the new MPC system has an average developing time of 4.1 ± 0.32 min (n = 20). For RCP values, the MPC and TLC data are well consistent (r = 0.94). The combined use of the microwave oven heating and the quick quality control system will facilitate the rapid emergency use of 99mTc-antimony trisulfide colloid.

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Authors and Affiliations

  1. Center of Biosciences, Kohat University of Science and Technology, Kohat, NWFP 25000, Pakistan

    Syed Qaiser Shah

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  1. Syed Qaiser Shah
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Translated from Zhurnal Obshchei Khimii, Vol. 75, No. 9, 2005, pp. 1418–1422.

Original Russian Text Copyright © 2005 by Shah.

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Shah, S.Q. Formulation of Technetium-99m Labeled Antimony Trisulfide Colloid, Intended for Sentinel Lymph Node Imaging, Using New Techniques. Russ J Gen Chem 75, 1346–1350 (2005). https://doi.org/10.1007/s11176-005-0424-6

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  • DOI: https://doi.org/10.1007/s11176-005-0424-6

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