Abstract
The data obtained earlier on the Mannich bases derived from natural and synthetic phenols are summarized, the structure—antioxidant activity relationship is analyzed, and the most active compounds among these bases are identified. The influence of the nature and position of aminomethyl substituents on the hemolytic activity (erythrotoxicity) is considered. The high antioxidant and membrane-protective activity exhibited by some Mannich bases in the model of oxidative hemolysis of mammalian erythrocytes is explained by the presence in their structure of a N-alkyl group or a fragment of a heterocyclic amine, which affects the lipophilicity of the compounds and the interaction with the cell membrane.
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This work was financially supported by the Ministry of Science and Higher Education of the Russian Federation (State Assignment Nos 122040600022-1 (assessment of antioxidant activity) and 122040600073-3 (synthesis of compounds)).
No human or animal subjects were used in this research.
Based on the materials of the XII All-Russian scientific conference with international participation and the School of young scientists “Chemistry and Technology of Plant Substances” (November 29—December 02, 2022, Kirov, Russia).
Published in Russian in Izvestiya AkademiiNauk. Seriya Khimicheskaya, Vol. 72, No. 9, pp. 1972–1990, September, 2023.
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Shevchenko, O.G., Buravlev, E.V. Antioxidant activity of Mannich bases derived from natural and synthetic phenols. Russ Chem Bull 72, 1972–1990 (2023). https://doi.org/10.1007/s11172-023-3991-y
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DOI: https://doi.org/10.1007/s11172-023-3991-y