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Modern synthesis of cognitive enhancers: cholinergic ligands

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Russian Chemical Bulletin Aims and scope

Abstract

The review outlines the methods for the synthesis of cognitive enhancers that are used as drugs that improve the cognitive abilities of healthy people or restore mental health of patients with pathologies. Information about the trials of cognitive enhancers and their effectiveness is summarized. The synthetic routes to these compounds are analyzed. The review focuses on the compounds acting on cholinergic receptors (acetylcholine receptors), namely muscarinic and nicotinic receptor ligands.

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Authors and Affiliations

  1. N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991, Moscow, Russian Federation

    F. V. Ryzhkov, Y. E. Ryzhkova, M. N. Elinson & M. P. Egorov

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  1. F. V. Ryzhkov
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  2. Y. E. Ryzhkova
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  3. M. N. Elinson
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Correspondence to F. V. Ryzhkov.

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Dedicated to Academician of the Russian Academy of Sciences I. P. Beletskaya on the occasion of her anniversary.

No human or animal subjects were used in this research.

The authors declare no competing interests.

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, Vol. 72, No. 4, pp. 819–837, April, 2023.

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Ryzhkov, F.V., Ryzhkova, Y.E., Elinson, M.N. et al. Modern synthesis of cognitive enhancers: cholinergic ligands. Russ Chem Bull 72, 819–837 (2023). https://doi.org/10.1007/s11172-023-3846-1

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  • DOI: https://doi.org/10.1007/s11172-023-3846-1

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