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Chromatographic analysis of meloxicam and metabolites of its biodegradation

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Abstract

A procedure for chromatographic analysis of meloxicam in post-fermentation media of Rhodococcus spp. using reverse-phase HPLC was developed. Selectivity, linearity, precision, and correctness of the procedure were confirmed by validation. The HPLC/MS conditions for an analysis of the meloxicam biodegradation products were determined. The developed methods make it possible to ensure the quality of the analytical procedures performed during the biodegradation of meloxicam. The factors affecting the biodegradation rate were established. The process of meloxicam biodegradation is adequately described by the first-order kinetic equations. The kinetic modeling allows one to reduce the experimental scale, to determine the half-life and duration of the process, and to select an efficient strain for meloxicam biodegradation.

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Authors and Affiliations

  1. Perm Federal Research Center, Ural Branch of the Russian Academy of Sciences, 13a ul. Lenina, 614990, Perm, Russian Federation

    E. V. Vikhareva, G. A. Bazhutin & E. A. Tyumina

  2. Perm State Pharmaceutical Academy, 2 ul. Polevaya, 614990, Perm, Russian Federation

    E. V. Vikhareva & Yu. N. Karpenko

  3. Perm National Research Polytechnic University, 29 Komsomol’skii prosp., 614990, Perm, Russian Federation

    A. A. Selyaninov

Authors
  1. E. V. Vikhareva
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  2. Yu. N. Karpenko
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  3. A. A. Selyaninov
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  4. G. A. Bazhutin
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  5. E. A. Tyumina
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Corresponding author

Correspondence to E. V. Vikhareva.

Additional information

This work was financially supported by the Russian Science Foundation (Project No. 21-14-00132).

No human or animal subjects were used in this research.

The authors declare no competing interests.

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 11, pp. 2358–2364, November, 2022.

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Vikhareva, E.V., Karpenko, Y.N., Selyaninov, A.A. et al. Chromatographic analysis of meloxicam and metabolites of its biodegradation. Russ Chem Bull 71, 2358–2364 (2022). https://doi.org/10.1007/s11172-022-3663-3

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  • DOI: https://doi.org/10.1007/s11172-022-3663-3

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