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Synthesis and properties of substituted 2-thioxohexahydropyrimidine-5-carbohydrazides

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Abstract

A regioselective method for the synthesis of substituted (4R*,5S*,6R*)-2-thioxohexahydro-pyrimidine-5-carbohydrazides from the corresponding diastereomers of hexahydro-2H-chromeno[4,3-d]pyrimidines was developed. In acidic medium, the obtained hydrazides are prone to retro reaction to give hexahydro-2H-chromeno[4,3-d]pyrimidines.

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Authors and Affiliations

  1. Yaroslavl State Technical University, 88 Moskovskii prosp., 150023, Yaroslavl, Russian Federation

    E. S. Makarova, M. V. Kabanova, A. S. Danilova, S. I. Filimonov & E. A. Smirnova

  2. Yaroslavl State Pedagogical University named after K. D. Ushinsky, M. V. Dorogov Pharmaceutical Technology Transfer Center, 108/1 ul. Respublikanskaya, 150000, Yaroslavl, Russian Federation

    A. A. Shetnev

Authors
  1. E. S. Makarova
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  2. M. V. Kabanova
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  3. A. S. Danilova
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  4. S. I. Filimonov
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  5. E. A. Smirnova
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  6. A. A. Shetnev
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Corresponding authors

Correspondence to S. I. Filimonov or A. A. Shetnev.

Additional information

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 7, pp. 1377–1382, July, 2021.

This paper does not contain descriptions of studies on animals or humans.

The authors declare no competing interests.

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Makarova, E.S., Kabanova, M.V., Danilova, A.S. et al. Synthesis and properties of substituted 2-thioxohexahydropyrimidine-5-carbohydrazides. Russ Chem Bull 70, 1377–1382 (2021). https://doi.org/10.1007/s11172-021-3226-z

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  • DOI: https://doi.org/10.1007/s11172-021-3226-z

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