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Design of SiO2/aminopropylsilane-modified magnetic Fe3O4 nanoparticles for doxorubicin immobilization

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Abstract

Surface modification of magnetic nanoparticles (MNPs) with tetramethylorthosilicate and 3-aminopropyltrimethoxysilane was studied. The use of N-phosphonomethyliminodiacetic acid for the stabilization of the initial MNPs can significantly increase the coating thickness and specific surface area of SiO2/APS-modified (APS is 3-aminopropylsilane) MNPs. The possibility of sorption of antitumor drug doxorubicin (DOX) on the synthesized nanoparticles was studied. The degree of sorption of DOX increases with an increase in the specific surface area of the particles.

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Authors and Affiliations

  1. I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 22 ul. S. Kovalevskoi, 620108, Ekaterinburg, Russian Federation

    A. M. Demin, A. V. Vakhrushev, M. S. Valova, V. P. Krasnov & V. N. Charushin

  2. Mikheev Institute of Metal Physics, Ural Branch of the Russian Academy of Sciences, 18 ul. S. Kovalevskoi, 620108, Ekaterinburg, Russian Federation

    A. S. Minin & M. A. Uimin

  3. Institute of Natural Sciences and Mathematics, Ural Federal University, 51 prosp. Lenina, 620000, Ekaterinburg, Russian Federation

    D. K. Kuznetsov & V. Ya. Shur

  4. Institute of Chemical Engineering, Ural Federal University named after the first President of Russia B. N. Yeltsin, 19 ul. Mira, 620002, Ekaterinburg, Russian Federation

    V. P. Krasnov & V. N. Charushin

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  1. A. M. Demin
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  2. A. V. Vakhrushev
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Correspondence to A. M. Demin.

Additional information

Dedicated to Academician of the Russian Academy of Sciences V. N. Charushin on the occasion of his 70th birthday.

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 5, pp. 987–994, May, 2021.

This work was financially supported by the Ministry of Science and Higher Education of the Russian Federation (Project No. 075-15-2020-777) using equipment of the Center for Joint Use “Spectroscopy and Analysis of Organic Compounds” (CJU “SAOC,” I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences) and Ural Center for Joint Use “Modern Nanotechnologies” of the Institute of Natural Sciences and Mathematics (Ural Federal University named after the first President of Russia B. N. Yeltsin).

This work does not involve human participants and animal subjects.

The authors declare that there is no conflict of interest in financial or any other sphere.

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Demin, A.M., Vakhrushev, A.V., Valova, M.S. et al. Design of SiO2/aminopropylsilane-modified magnetic Fe3O4 nanoparticles for doxorubicin immobilization. Russ Chem Bull 70, 987–994 (2021). https://doi.org/10.1007/s11172-021-3177-4

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