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Kinetic modeling of dynamic processes in the cholinergic synapse

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Abstract

A kinetic model describing the dynamics of synaptic “discharge”, taking into account the kinetics of the neurotransmitter injection into the synaptic cleft, pH dependence of the enzyme catalytic activity, and proton removal by diffusion was proposed and studied. In the framework of the kinetic model, functioning of the cholinergic synapse was considered. The results of mathematical modeling of the change in the acetylcholine level, induced pH impulse, and the effect of the impulse transmission frequency and acetylcholinesterase inhibition are presented. A physicochemical interpretation was given for a number of key important physiological phenomena, such as neuromuscular paralysis, the mechanism of information recording and storage in the neurological memory, the action of nerve poisons and toxins, and Alzheimer’s disease.

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Authors and Affiliations

  1. Institute of Physicochemical Foundations of the Functioning of Neural Network and Artificial Intelligence, Lomonosov Moscow State University, 1 Leninskie Gory, 119991, Moscow, Russian Federation

    S. D. Varfolomeev

  2. N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, 4 ul. Kosygina, 119334, Moscow, Russian Federation

    S. D. Varfolomeev, V. I. Bykov & S. B. Tsybenova

Authors
  1. S. D. Varfolomeev
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  2. V. I. Bykov
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  3. S. B. Tsybenova
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Correspondence to S. B. Tsybenova.

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Dedicated to Academician of the Russian Academy of Sciences A. M. Muzafarov on the occasion of his 70th birthday.

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 8, pp. 1585–1593, August, 2020.

This work was financially supported by the Russian Science Foundation (Project No. 18-13-00030).

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Varfolomeev, S.D., Bykov, V.I. & Tsybenova, S.B. Kinetic modeling of dynamic processes in the cholinergic synapse. Russ Chem Bull 69, 1585–1593 (2020). https://doi.org/10.1007/s11172-020-2939-8

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  • DOI: https://doi.org/10.1007/s11172-020-2939-8

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