Abstract
Synthetic approaches were proposed to the development of hybrid organic—inorganic systems based on giant Keplerate polyoxometalates (POM Mo132), biocompatible polymers, and fluorescent molecules. A concept was formulated for the production of new systems for the prolonged release of drugs bearing a constant or temporary (protonated group) positive charge and fluorescent labels for tissue staining during electrophoretic introduction. In particular, a possibility of covalent functionalization of the POM Mo132 surface by the organosilicon molecules (aminopropyltrimethoxysilane) was shown. A promising procedure of the synthesis of NHS-esters of rhodamine B for the subsequent inclusion into the hybrid system was developed. The kinetic studies of POM destruction in an aqueous medium were carried out. The influence of association of rhodamine B with Mo132 on the character of fluorescence was studied.
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The authors are grateful to M. Yu. Kornev for an important contribution to the discussion of the results of NMR spectroscopy.
This work was financially supported by the Russian Science Foundation (Project No. 19-73-00177).
Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 4, pp. 0804–0814, April, 2020.
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Grzhegorzhevskii, K.V., Shevtsev, N.S., Abushaeva, A.R. et al. Prerequisites and prospects for the development of novel systems based on the Keplerate type polyoxomolybdates for the controlled release of drugs and fluorescent molecules. Russ Chem Bull 69, 804–814 (2020). https://doi.org/10.1007/s11172-020-2836-1
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DOI: https://doi.org/10.1007/s11172-020-2836-1