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New 1-(2-chloroquinolin-3-yl)-4-dimethylamino-2-(naphthalen-1-yl)-1-phenylbutan-2-ols with antituberculosis activity

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Abstract

New 4-dimethylamino-2-(naphthalen-1-yl)-1-phenyl-1-(quinolin-3-yl)butan-2-ols with antituberculosis activity were synthesized. (1R*,2S*)-1-(6-Bromo-2-chloroquinolin-3-yl)-4-dimethylamino-2-(naphthalen-1-yl)-1-phenylbutan-2-ol hydrocitrate exhibiting high antituberculosis activity is in the final stage of clinical trials and is prepared for use in clinical practice.

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References

  1. V. Baptiste, C. Crauste, M. Flipo, A. R. Baulard, B. Deprez, N. Willand, Eur. J. Med. Chem., 2012, 51, 1.

    Article  Google Scholar 

  2. A. V. Omel’kov, V. E. Fedorov, Tez. dokl. II Mezhdistsiplinarnogo simpoziuma i molodezhnogo foruma po meditsinskoi, organicheskoi i biologicheskoi khimii (2015, pos. Novyi Svet (Krym)) [Abstrs. of Papers, IInd Interdisciplinary Symposium and Youth Forum on Medicinal, Organic, and Biological Chemistry (2015, Novy Svet, Crimea)], Department of Chemistry, M. V. Lomonosov Moscow State University, 2015, p. 169 (in Russian).

  3. A. V. Omel’kov, V. E. Fedorov, Tez. dokl. IV Mezhdistsiplinarnogo simpoziuma i molodezhnogo foruma po meditsinskoi, organicheskoi i biologicheskoi khimii (2018, pos. Novyi Svet, Krym) [Abstrs. of Papers, IVth Interdisciplinary Symposium and Youth Forum on Medicinal, Organic, and Biological Chemistry (2018, Novy Svet, Crimea)], Izd-vo Pero, Moscow, 2018, p. 166 (in Russian).

    Google Scholar 

  4. K. Andries, P. Verhasselt, J. Guillemont, H. W. H. Gohlmann, J.-M. Neefs, H. Winker, J. Van Gestel, P. Timmerman, M. Zhu, E. Lee, P. Williams, D. de Chaffoy, E. Huitric, S. Hoffner, E. Cambau, C. Truffot-Pernot, N. Lounis, V. Jarlier, Science, 2005, 307, 223.

    Article  CAS  Google Scholar 

  5. A. Koul, N. Dendouga, B. Molenberghs, L. Vranckx, R. Willebrords, Z. Ristic, H. Lill, I. Dorange, J. Guillemont, D. Bald, K. Andries, Nat. Chem. Biol., 2007, 3, 6, 323.

    Article  Google Scholar 

  6. S. Petrella, E. Cambau, A. Chauffour, K. Andries, V. Jarlier, W. Sougakoff, Antimicrobial Agents and Chemotherapy, August 2006, 50, 8, 2853.

    Article  CAS  Google Scholar 

  7. WO 2007/000436; https://doi.org/worldwide.espacenet.com.

  8. CN105085395A; https://doi.org/worldwide.espacenet.com.

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Authors and Affiliations

  1. Pharm-Sintez, Build. 134, 29 ul. Vereyskaya, 121357, Moscow, Russian Federation

    A. V. Omel’kov, V. E. Fedorov & A. A. Stepanov

Authors
  1. A. V. Omel’kov
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  2. V. E. Fedorov
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  3. A. A. Stepanov
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Corresponding author

Correspondence to A. V. Omel’kov.

Additional information

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 10, pp. 1908–1918, October, 2019.

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Omel’kov, A.V., Fedorov, V.E. & Stepanov, A.A. New 1-(2-chloroquinolin-3-yl)-4-dimethylamino-2-(naphthalen-1-yl)-1-phenylbutan-2-ols with antituberculosis activity. Russ Chem Bull 68, 1908–1918 (2019). https://doi.org/10.1007/s11172-019-2646-5

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  • DOI: https://doi.org/10.1007/s11172-019-2646-5

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