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Hetarylfuroxans: cytotoxic effect and induction of apoptosis in chronic myeloid leukemia K562 cells

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Abstract

Hetarylfuroxans (4-(2-methylpyridin-5-yloxy)-3-phenylfuroxan (1), bis(1,2,4-oxadiazol- 3-yl)furoxan (2), and 4-amino-3-(indenotriazin-3-yl)furoxan (3)) exhibit in vitro cytotoxic activity against chronic myeloid leukemia K562 cells. All studied furoxans induce apoptosis in K562 cells. The experiments with activation of caspases-3 and -7 showed that furoxan 3 possessed the highest apoptosis-inducing capacity. The studied hetarylfuroxans were found to be the promising drug candidates for the treatment of chronic myeloid leukemia K562.

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Authors and Affiliations

  1. Institute of Physiologically Active Compounds, Russian Academy of Sciences, 1 Severnyi proezd, 142432, Chernogolovka, Moscow Region, Russian Federation

    S. A. Pukhov & L. A. Anikina

  2. N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991, Moscow, Russian Federation

    A. A. Larin, L. L. Fershtat, A. S. Kulikov & N. N. Makhova

Authors
  1. S. A. Pukhov
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  2. L. A. Anikina
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  3. A. A. Larin
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  4. L. L. Fershtat
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  5. A. S. Kulikov
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  6. N. N. Makhova
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Corresponding author

Correspondence to N. N. Makhova.

Additional information

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 1, pp. 0158–0162, January, 2019.

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Pukhov, S.A., Anikina, L.A., Larin, A.A. et al. Hetarylfuroxans: cytotoxic effect and induction of apoptosis in chronic myeloid leukemia K562 cells. Russ Chem Bull 68, 158–162 (2019). https://doi.org/10.1007/s11172-019-2431-5

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  • DOI: https://doi.org/10.1007/s11172-019-2431-5

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