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Analysis of racemic conjugates of purine with heterocyclic amines by chiral high-performance liquid chromatography

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Abstract

Reversed-phase HPLC on chiral stationary phases was used to study the influence of the structure of purine and 2-aminopurine conjugates with chiral heterocyclic amines on the retention times. The optimum conditions for separation of enantiomers were found. The best parameters of separation of stereoisomers of all the compounds examined were achieved on a (S,S)-Whelk-O1 column in weakly alkaline aqueous methanol systems.

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Authors and Affiliations

  1. I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 22/20 ul. S. Kovalevskoi, 620990, Ekaterinburg, Russian Federation

    A. A. Tumashov, D. A. Gruzdev, A. Yu. Vigorov, V. V. Musiyak, E. N. Chulakov, G. L. Levit, V. P. Krasnov & V. N. Charushin

  2. Institute of Natural Sciences and Mathematics, Ural Federal University, 19 ul. Mira, 620002, Ekaterinburg, Russian Federation

    A. A. Tumashov

  3. Institute of Chemical Engineering, Ural Federal University, 19 ul. Mira, 620002, Ekaterinburg, Russian Federation

    V. N. Charushin

Authors
  1. A. A. Tumashov
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  2. D. A. Gruzdev
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  3. A. Yu. Vigorov
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  4. V. V. Musiyak
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  5. E. N. Chulakov
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  6. G. L. Levit
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  7. V. P. Krasnov
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  8. V. N. Charushin
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Additional information

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 9, pp. 1704–1709, September, 2018.

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Tumashov, A.A., Gruzdev, D.A., Vigorov, A.Y. et al. Analysis of racemic conjugates of purine with heterocyclic amines by chiral high-performance liquid chromatography. Russ Chem Bull 67, 1704–1709 (2018). https://doi.org/10.1007/s11172-018-2279-0

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  • DOI: https://doi.org/10.1007/s11172-018-2279-0

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