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Synthesis of purine and 2-aminopurine conjugates bearing the fragments of heterocyclic amines at position 6

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Chemistry of Heterocyclic Compounds Aims and scope

A series of novel N-(purin-6-yl)- and N-(2-aminopurin-6-yl) derivatives of heterocyclic amines was synthesized. It was found that preferred preparative method for N-(purin-6-yl) derivatives of heterocyclic amines is interaction of 6-chloropurine with heterocyclic amines without any catalyst; whereas N-(2-aminopurin-6-yl) derivatives were obtained in the moderate-to-high yields while heating 2-amino-6-chloropurine and heterocyclic amines in water in the presence of sulfuric acid.

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  1. Eletskaya, B. Z.; Konstantinova, I. D.; Paramonov, A. S.; Esipov, R. S.; Gruzdev, D. A.; Vigorov, A. Yu.; Levit, G. L.; Miroshnikov, A. I.; Krasnov, V. P.; Charushin, V. N. Mendeleev Commun. 2015, in press.

  2. Eletskaya, B. Z.; Konstantinova, I. D.; Paramonov, A. S.; Esipov, R. S.; Gruzdev, D. A.; Vigorov, A. Yu.; Levit, G. L.; Miroshnikov, A. I.;

    Krasnov, V. P.; Charushin, V. N. Mendeleev Commun. 2015, in press

  3. Eletskaya, B. Z.; Konstantinova, I. D.; Paramonov, A. S.; Esipov, R. S.; Gruzdev, D. A.; Vigorov, A. Yu.; Levit, G. L.; Miroshnikov, A. I.; Krasnov, V. P.; Charushin, V. N. Mendeleev Commun. 2015, in press.

  4. Eletskaya, B. Z.; Konstantinova, I. D.; Paramonov, A. S.; Esipov, R. S.; Gruzdev, D. A.; Vigorov, A. Yu.; Levit, G. L.; Miroshnikov, A. I.; Krasnov, V. P.; Charushin, V. N. Mendeleev Commun. 2015, in press.

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Authors and Affiliations

  1. I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 22 S. Kovalevskoi / 20 Akademicheskaya St., Yekaterinburg, 620990, Russia

    Dmitry A. Gruzdev, Vera V. Musiyak, Evgeny N. Chulakov, Galina L. Levit & Victor P. Krasnov

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  1. Dmitry A. Gruzdev
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  2. Vera V. Musiyak
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  3. Evgeny N. Chulakov
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  4. Galina L. Levit
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  5. Victor P. Krasnov
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Correspondence to Dmitry A. Gruzdev.

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Gruzdev, D.A., Musiyak, V.V., Chulakov, E.N. et al. Synthesis of purine and 2-aminopurine conjugates bearing the fragments of heterocyclic amines at position 6. Chem Heterocycl Comp 51, 738–744 (2015). https://doi.org/10.1007/s10593-015-1767-5

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  • DOI: https://doi.org/10.1007/s10593-015-1767-5

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