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Russian Chemical Bulletin

, Volume 66, Issue 11, pp 2157–2164 | Cite as

Conjugates of natural chlorins and isobornylphenols with a different length of the spacer between the chlorin and terpenephenolic fragments: synthesis and antioxidant activity

  • I. S. Khudyaeva
  • D. V. Belykh
  • O. G. Shevchenko
  • M. A. Maximova
  • L. F. Zainullina
  • Yu. V. Vakhitova
  • O. V. Shchukina
  • E. V. Buravlev
  • I. Yu. Chukicheva
  • A. V. Kutchina
Full Article

Abstract

Conjugates containing chlorine and isobornylphenolic fragments, which are connected by spacers of different lengths, were synthesized from methyl pheophorbide a. The toxicity and antioxidant activity of the obtained compounds were studied. Derivatives of pyropheophorbide a containing the most distant from the macrocycle terpenephenolic fragment combine a low toxicity with the high antioxidant activity, and are the most promising for further designing of new medicinal agents for the treatment of diseases associated with a disorder in oxidation-reduction processes in the body.

Key words

methyl pheophorbide a pyropheophorbide a chlorin e6 isobornylphenols antioxidant activity (AOA) lipid peroxidation (LPO) human embryonic kidney cells 293 (HEK 293) SH-SY5Y neuroblastoma cells viability 

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2017

Authors and Affiliations

  • I. S. Khudyaeva
    • 1
  • D. V. Belykh
    • 1
  • O. G. Shevchenko
    • 2
  • M. A. Maximova
    • 3
  • L. F. Zainullina
    • 3
    • 4
  • Yu. V. Vakhitova
    • 3
    • 4
  • O. V. Shchukina
    • 1
  • E. V. Buravlev
    • 1
  • I. Yu. Chukicheva
    • 1
  • A. V. Kutchina
    • 1
  1. 1.Institute of Chemistry, Komi Scientific CentreUral Branch of the Russian Academy of SciencesSyktyvkarRussian Federation
  2. 2.Institute of Biology, Komi Scientific CentreUral Branch of the Russian Academy of SciencesSyktyvkarRussian Federation
  3. 3.Institute of Biochemistry and GeneticsUfa Scientific Centre of the Russian Academy of SciencesUfaRussian Federation
  4. 4.V. V. Zakusov Institute of PharmacologyMoscowRussian Federation

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