Conjugates of natural chlorins and isobornylphenols with a different length of the spacer between the chlorin and terpenephenolic fragments: synthesis and antioxidant activity
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Conjugates containing chlorine and isobornylphenolic fragments, which are connected by spacers of different lengths, were synthesized from methyl pheophorbide a. The toxicity and antioxidant activity of the obtained compounds were studied. Derivatives of pyropheophorbide a containing the most distant from the macrocycle terpenephenolic fragment combine a low toxicity with the high antioxidant activity, and are the most promising for further designing of new medicinal agents for the treatment of diseases associated with a disorder in oxidation-reduction processes in the body.
Key wordsmethyl pheophorbide a pyropheophorbide a chlorin e6 isobornylphenols antioxidant activity (AOA) lipid peroxidation (LPO) human embryonic kidney cells 293 (HEK 293) SH-SY5Y neuroblastoma cells viability
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