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Synthesis and pharmacological activity of 2-(biphenyl-4-yl)imidazo[1,2-a]benzimidazoles

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Abstract

An efficient method for the synthesis of novel 9H-imidazo[1,2-a]benzimidazole derivatives containing a biphenyl substituent at position 2 was developed. These compounds, belonging to the privileged substructures, have been tested for a wide range of pharmacological activities in the in vitro test panel. It was shown that the synthesized derivatives demonstrated high antioxidant activity, some of them inhibit type 1B protein tyrosine phosphatase, activate AMP-activated protein kinase, possess antiplatelet properties, and a rare and very interesting kind of activity, the ability to break cross-links of glycated proteins. The most active compounds can be suggested for further optimization.

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Authors and Affiliations

  1. Volgograd State Medical University, the Ministry of Healthcare of the Russian Federation, 1 pl. Pavshikh Bortsov, 400131, Volgograd, Russian Federation

    A. A. Spasov, A. A. Brigadirova, V. A. Sysoeva, A. I. Rashchenko, R. A. Litvinov, O. Yu. Mayka & D. A. Babkov

  2. Volgograd Medical Scientific Center, 1 pl. Pavshikh Bortsov, 400131, Volgograd, Russian Federation

    A. A. Spasov & A. A. Brigadirova

  3. Institute of Physical and Organic Chemistry, Southern Federal University, 194/2 prosp. Stachki, 344090, Rostov-on-Don, Russian Federation

    O. N. Zhukovskaya, H. S. A. Abbas, V. A. Anisimova & A. S. Morkovnik

Authors
  1. A. A. Spasov
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  2. O. N. Zhukovskaya
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  3. A. A. Brigadirova
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  4. H. S. A. Abbas
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  5. V. A. Anisimova
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  6. V. A. Sysoeva
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  7. A. I. Rashchenko
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  8. R. A. Litvinov
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  9. O. Yu. Mayka
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  10. D. A. Babkov
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  11. A. S. Morkovnik
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Corresponding authors

Correspondence to A. A. Spasov or A. S. Morkovnik.

Additional information

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 10, pp. 1905—1912, October, 2017.

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Spasov, A.A., Zhukovskaya, O.N., Brigadirova, A.A. et al. Synthesis and pharmacological activity of 2-(biphenyl-4-yl)imidazo[1,2-a]benzimidazoles. Russ Chem Bull 66, 1905–1912 (2017). https://doi.org/10.1007/s11172-017-1965-7

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  • DOI: https://doi.org/10.1007/s11172-017-1965-7

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