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Synthesis and Pharmacological Activity of Trifluoromethyl-Containing Imidazo[1,2-A]Benzimidazoles

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A series of 2-(4-trifluoromethylphenyl)- and 2-trifluoromethyl-9-dialkylaminoalkylimidazo[1,2-a]benzimidazoles were synthesized for the first time by reacting 2-amino-1-dialkylaminoalkylbenzimidazoles and 2-bromo-1-[(4-trifluoromethyl)phenyl]ethanone or 1-bromo-3,3,3-trifluoroacetone and were tested for analgesic and antiplatelet activity, glycogen phosphorylase and dipeptidyl peptidase-4 inhibitory activity, and in vitro glycation of bovine serum albumin.

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Acknowledgments

The work was financed in part by the project part of a state task for scientific activity, Project No. 4.196.2014/K. Pharmacological properties of the synthesized compounds were studied under the direction of A. A. Spasov through a grant of the Russian Science Foundation (Project No. 14-25-00139).

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Authors and Affiliations

  1. Institute of Physical and Organic Chemistry, Southern Federal University, Rostov-on-Don, Russia

    O. N. Zhukovskaya, T. A. Kuz’menko, A. S. Morkovnik & V. A. Anisimova

  2. Volgograd State Medical University, Volgograd, 400131, Russia

    A. A. Spasov, A. F. Kucheryavenko, O. A. Salaznikova, K. A. Gaidukova, V. A. Kuznetsova, D. A. Babkov, O. Yu. Grechko, N. V. Eliseeva & A. I. Rashchenko

  3. Volgograd Medical Scientific Center, Volgograd, 400131, Russia

    A. A. Spasov

Authors
  1. O. N. Zhukovskaya
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  2. A. A. Spasov
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  3. T. A. Kuz’menko
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  4. A. S. Morkovnik
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  5. A. F. Kucheryavenko
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  6. V. A. Anisimova
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  7. O. A. Salaznikova
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  8. K. A. Gaidukova
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  9. V. A. Kuznetsova
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  10. D. A. Babkov
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  11. O. Yu. Grechko
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  12. N. V. Eliseeva
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  13. A. I. Rashchenko
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Corresponding author

Correspondence to O. N. Zhukovskaya.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 52, No. 5, pp. 3 – 9, May, 2018.

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Zhukovskaya, O.N., Spasov, A.A., Kuz’menko, T.A. et al. Synthesis and Pharmacological Activity of Trifluoromethyl-Containing Imidazo[1,2-A]Benzimidazoles. Pharm Chem J 52, 385–391 (2018). https://doi.org/10.1007/s11094-018-1826-1

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  • DOI: https://doi.org/10.1007/s11094-018-1826-1

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