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Synthesis and membrane-protective activity of 4-aminomethyl derivatives of 2,6-diisobornylphenol

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Abstract

A series of 4-aminomethyl derivatives of 2,6-diisobornylphenol containing tertiary and secondary amino groups were synthesized. Their toxicity and the membrane-protective and antioxidant activity were assessed using red blood cells of laboratory mice as the test object. These compounds were shown to exhibit high membrane-protective and antioxidant activity, which substantially depends on the structure of the substituent and the concentration of the substance.

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Correspondence to I. Yu. Chukicheva.

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Dedicated to Academician of the Russian Academy of Sciences R. Z. Sagdeev on the occasion of his 75th birthday.

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 1, pp. 0091—0098, January, 2017.

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Buravlev, E.V., Chukicheva, I.Y., Shevchenko, O.G. et al. Synthesis and membrane-protective activity of 4-aminomethyl derivatives of 2,6-diisobornylphenol. Russ Chem Bull 66, 91–98 (2017). https://doi.org/10.1007/s11172-017-1705-z

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  • DOI: https://doi.org/10.1007/s11172-017-1705-z

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