Along with microangiopathy, one of the main causes of blindness in diabetic retinopathy consists of degeneration of retinal neurons. Electron microscopy and morphometric analysis were used to study structural changes in neurosensory cells, associative, and ganglion neurons in the retina in 30 while mongrel male rats with streptozotocin diabetes for two months and the effects of a new semisynthetic antioxidant 4-methyl-2,6-diisobornylphenol, a screened phenol, were evaluated. Destructive changes were found to affect the outer segments of neurosensory cells and ganglion neurons. The number density of neurosensory and ganglion cells decreased, and the proportion of these cells with pyknotic nuclei increased. 4-Methyl-2,6-diisobornylphenol had neuroprotective actions, preventing destructive changes to neurosensory cells and ganglion neurons.
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References
M. I. Balabolkin and E. M. Klebanov, “The role of oxidative stress in the pathogenesis of the vascular complications of diabetes mellitus (lecture),” Ter. Arkh., 73, No. 4, 3–8 (2000).
I. S. Ivanov and V. I. Smolyakova, “Effects of an o-isobornylphenol derivative on lipid peroxidation in brain tissues in rats subjected to ischemia,” in: Human Science: Proc. IX Congr. of Young Scientists and Specialists [in Russian], Siberian State Medical University Press, Tomsk (2008), pp. 111–112.
E. A. Kravchuk, “Free-radical oxidation in the pathogenesis of eye diseases,” Vestn. Oftalmol., No. 5, 48–51 (2004).
E. B. Menshchikova, V. Z. Lankin, N. K. Zenkov, et al., Oxidative Stress. Prooxidants and Antioxidants [in Russian], Slovo, Moscow (2006).
T. M. Milenkaya, L. N. Shcherbacheva, and V. S. Terentiev, “Diabetic retinopathy, diagnosis, treatment,” Ros. Med. Zh., 6, No. 12, 8–15 (1998).
M. B. Plotnikov, I. S. Ivanov, V. I. Smolyakova, et al., “New isobornylphenol derivatives as the basis for developing substances for the prescription and treatment of thrombophilic states,” in: Chemistry and Medicine: Proc. VI All-Rus. Sci. Seminar and Young Scientists’ School [in Russian], Gilem, Ufa (2007), pp. 80–81.
M. B. Plotnikov, V. I. Smolyakova, I. S. Ivanov, et al., “The hemorheological activity o-isobornylphenol derivatives,” in: Hemorheology and the Microcirculation: Int. Conf. Proc. [in Russian], Ushinskii Yaroslavl State Pedagogical University Press, Yaroslavl (2007), p. 160.
V. Kh. Khavinson and S. V. Trofimova, “Bioregulatory peptides in the treatment of diabetic retinopathy,” in: Proc. VII Congr. of Russian Ophthalmologists [in Russian], Fedorov Center Press, Moscow (2000), Part 1, p. 335.
V. Asnaghi, C. Gerhardinger, T. Hoehn, et al., “A role for the polyol pathway in the early neuroretinal apoptosis and glial changes induced by diabetes in the rat,” Diabetes, 52, No. 2, 506–511 (2003).
T. Bensaoula and A. Ottlecz, “Biochemical and ultrastructural studies in the neural retina and retinal pigment epithelium of STZ-diabetic rats: effect of captopril,” J. Ocul. Pharmacol. Ther., 17, No. 6, 573–586 (2001).
A. Ceriello, N. Bortolotti, E. Motz, et al., “Meal-induced oxidative stress and low-density lipoprotein oxidation in diabetes: the possible role of hyperglycemia,” Metabolism, 48, No. 12, 1503–1508 (1999).
P. M. Martin, P. Roon, T. K. Ellis, et al., “Death of retinal neurons in streptozotocin-induced diabetic mice,” Invest. Ophthalmol. Vis. Sci., 45, 3330–3336 (2004).
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Translated from Morfologiya, Vol. 136, No. 5, pp. 42–45, September–October, 2009.
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Logvinov, S.V., Plotnikov, M.B., Zhdankina, A.A. et al. Morphological Changes in Retinal Neurons in Streptozotocin-Induced Diabetes Mellitus and Their Correction with an Isobornylphenol Derivative. Neurosci Behav Physi 40, 779–782 (2010). https://doi.org/10.1007/s11055-010-9326-0
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DOI: https://doi.org/10.1007/s11055-010-9326-0