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Molecular construction of multitarget neuroprotectors 4.* Synthesis and biological activity of conjugates of carbazoles and tetrahydrocarbazoles

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Unknown conjugates of carbazoles and tetrahydrocarbazoles were obtained by the alkylation of carbazoles and tetrahydrocarbazoles with 3,6-substituted 9-oxiranylmethylcarbazoles. The influence of synthesized 1-(9Н-carbazol-9-yl)-3-(1,2,3,4-tetrahydro-5Н-pyrido[4,3-b]-indol-5-yl)propan-2-ones on functional characteristics of brain mitochondria has been studied. The potential neuroprotective activity of a several representatives of conjugates has been demonstrated using glutamate toxicity model.

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Authors and Affiliations

  1. Institute of Physiologically Active Substances, Russian Academy of Sciences, 1 Severnyi proezd, 142432, Chernogolovka, Moscow Region, Russian Federation

    V. B. Sokolov, A. Yu. Aksinenko, T. V. Goreva, T. A. Epishina, L. G. Dubova, E. S. Dubrovskaya, S. G. Klochkov, P. N. Shevtsov, E. F. Shevtsova & S. O. Bachurin

Authors
  1. V. B. Sokolov
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  2. A. Yu. Aksinenko
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  3. T. V. Goreva
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  4. T. A. Epishina
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  5. L. G. Dubova
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  6. E. S. Dubrovskaya
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  7. S. G. Klochkov
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  8. P. N. Shevtsov
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  9. E. F. Shevtsova
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  10. S. O. Bachurin
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Corresponding author

Correspondence to V. B. Sokolov.

Additional information

For Part 3 see Ref. 1

Based on materials of the IV all-Russian Conference on Organic Chemistry and the XVIII Youth School-Conference on Organic Chemistry (November 22—27, 2015, Moscow, Russia).

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 9, pp. 2306—2311, September, 2016.

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Sokolov, V.B., Aksinenko, A.Y., Goreva, T.V. et al. Molecular construction of multitarget neuroprotectors 4.* Synthesis and biological activity of conjugates of carbazoles and tetrahydrocarbazoles. Russ Chem Bull 65, 2306–2311 (2016). https://doi.org/10.1007/s11172-016-1582-x

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  • DOI: https://doi.org/10.1007/s11172-016-1582-x

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