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Influence of water-soluble derivatives of [60]fullerene on catalytic activity of monoaminе oxidase B and their membranotropic properties

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Abstract

The effect of two water-soluble derivatives of [60]fullerene (WS[60]FDs) on mitochondrial monoamine oxidase B (MAO-B) involved in oxidative deamination of biogenic amines has been investigated. The studied compounds were shown to be inhibitors of MAO-B. The inhibitory mechanism and the inhibition constants were determined. It was shown that WS[60]FDs I and II penetrate in lipid bilayer of membrane of phosphatidylcholine liposomes and localize in the regions of both polar head and fatty acid groups of phospholipids. The equilibrium constants of fluorescent dye—WS[60]FDs complexes were determined.

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Authors and Affiliations

  1. Institute of Problems of Chemical Physics, Russian Academy of Sciencies, 1 prosp. Acad. Semenova, 142432, Chernogolovka, Moscow Region, Russian Federation

    A. V. Smolina, R. A. Kotelnikova, D. A. Poletaeva, P. A. Troshin, E. A. Khakina, A. V. Zhilenkov, Yu. V. Soldatova, V. N. Shtolko, G. N. Bogdanov & A. I. Kotelnikov

  2. Institute of Physiologically Active Compounds, Russian Academy of Sciencies, 1 Severny proezd, 142432, Chernogolovka, Moscow Region, Russian Federation

    V. V. Grigoriev

Authors
  1. A. V. Smolina
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  2. R. A. Kotelnikova
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  3. D. A. Poletaeva
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  4. P. A. Troshin
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  5. E. A. Khakina
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  6. A. V. Zhilenkov
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  7. Yu. V. Soldatova
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  8. V. N. Shtolko
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  9. V. V. Grigoriev
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  10. G. N. Bogdanov
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  11. A. I. Kotelnikov
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Correspondence to A. I. Kotelnikov.

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Dedicated to Academician of the Russian Academy of Sciences N. S. Zefirov on the occasion of his 80th birthday.

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 3, pp. 0784—0789, March, 2016.

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Smolina, A.V., Kotelnikova, R.A., Poletaeva, D.A. et al. Influence of water-soluble derivatives of [60]fullerene on catalytic activity of monoaminе oxidase B and their membranotropic properties. Russ Chem Bull 65, 784–789 (2016). https://doi.org/10.1007/s11172-016-1374-3

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  • DOI: https://doi.org/10.1007/s11172-016-1374-3

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