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Esterase profiles of hexafluoropropan-2-ol-based dialkyl phosphates as a major determinant of their effects in mouse brain in vivo

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Abstract

The relationship between the esterase profiles of two O-phosphorylated hexafluoropropan2-ols and their inhibitory activities and selectivities against mouse brain esterases was studied on brain preparations and in the whole animals. The predictions made from the analysis of esterase profiles of the studied organophosphorus compounds were found to be in complete agreement with their in vivo inhibitory activities against acetylcholinesterase, butyrylcholinesterase, and neuropathy target esterase.

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Authors and Affiliations

  1. Institute of Physiologically Active Compounds, Russian Academy of Sciences, 1 Severnyi proezd, 142432, Chernogolovka, Moscow region, Russian Federation

    G. F. Makhaeva, E. V. Rudakova, O. G. Serebryakova, A. Yu. Aksinenko & S. O. Bachurin

  2. Department of Environmental Health Sciences, University of Michigan, Ann Arbor, Michigan, 48109-2029, USA

    R. J. Richardson

Authors
  1. G. F. Makhaeva
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  2. E. V. Rudakova
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  3. O. G. Serebryakova
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  4. A. Yu. Aksinenko
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  5. R. J. Richardson
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  6. S. O. Bachurin
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Corresponding author

Correspondence to G. F. Makhaeva.

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Dedicated to Academician of the Russian Academy of Sciences N. S. Zefirov on the occasion of his 80th birthday.

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 9, pp. 2203–2209, September, 2015.

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Makhaeva, G.F., Rudakova, E.V., Serebryakova, O.G. et al. Esterase profiles of hexafluoropropan-2-ol-based dialkyl phosphates as a major determinant of their effects in mouse brain in vivo . Russ Chem Bull 64, 2203–2209 (2015). https://doi.org/10.1007/s11172-015-1139-4

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  • DOI: https://doi.org/10.1007/s11172-015-1139-4

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