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Endothelial glycocalyx as an orchestrator of vascular homeostasis. New research problems and prospects for vessel wall protection

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Abstract

The functions of endothelial glycocalyx as a regulator of plasma homeostasis and vessel wall homeostasis were considered. The state-of-the-art data of glycocalyx damage by some pathological processes were integrated. The topical task for protection and restoration of the damaged glycocalyx by therapeutic means was formulated. The research approaches for the search for such agents were surveyed and good prospects of multi-disciplinary development of the agents by specialists in different fields were emphasized.

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Authors and Affiliations

  1. Institute of Experimental Cardiology, Russian Cardiology Research and Production Complex, Ministry of Health of the Russian Federation, 15A ul. 3ya Cherepkovskaya, Russian Federation, 121552, Moscow, Russian Federation

    A. V. Maksimenko

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  1. A. V. Maksimenko
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Correspondence to A. V. Maksimenko.

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Dedicated to Academician of the Russian Academy of Sciences N. S. Zefirov on the occasion of his 80th birthday.

Based on the Proceedings of the First Russian Conference on Medicinal Chemistry (MedChem, Moscow, 2013) and the First Interdisciplinary Symposium on Medicinal, Organic, and Biological Chemistry, MedOrgBioChem-2014 (MOBI-Him2014, Crimea, Novyi Svet settlement, May 25–28, 2014).

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 9, pp. 2036–2042, September, 2015.

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Maksimenko, A.V. Endothelial glycocalyx as an orchestrator of vascular homeostasis. New research problems and prospects for vessel wall protection. Russ Chem Bull 64, 2036–2042 (2015). https://doi.org/10.1007/s11172-015-1114-0

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