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Design of a hybrid nanostructure based on fullerene C60 and biologically active substance for modeling physiological properties of compounds

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Abstract

The effects of cognitive-stimulating substance BD-2 of the γ-carboline family and a hybrid compound based on fullerene C60 and attached BD-2 on various aspects of the behavior of animals were studied. The synthesized hybrid fullerene compound (HFC) has no side psychostimulating effect characteristic of BD-2 but fully retains the properties of a cognitive-stimulating agent. The design of hybrid compounds based on fullerene C60 and pharmacologically active groups can be one of the ways for optimizing therapeutically promising compounds.

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References

  1. R. A. Kotelnikova, A. I. Kotelnikov, G. N. Bogdanov, V. S. Romanova, E. F. Kuleshova, M. E. Vol’pin, FEBS Lett., 1996, 389, 111.

    Article  CAS  Google Scholar 

  2. G. N. Bogdanov, R. A. Kotel’nikova, E. S. Frog, V. N. Shtol’ko, V. S. Romanova, Yu. N. Bubnov, Dokl. Biochem. Biophys. (Engl. Transl.), 2004, 396, 165 [Dokl. Akad. Nauk, 2004, 396, 401].

    Article  CAS  Google Scholar 

  3. P. J. Krustic, E. Wasserman, P. N. Keizer, J. R. Morton, K. F. Preston, Science, 1991, 254, 1183.

    Article  Google Scholar 

  4. I. Y. Podolski, Z. A. Podlubnaya, E. A. Kosenko, E. A. Mugantseva, E. G. Makarova, L. G. Marsagishvili, M. D. Shpagina, Y. G. Kaminsky, G. V. Andrievsky, V. K. Klochkov, J. Nanosci. Nanotechnol., 2007, 7, 1479.

    Article  CAS  Google Scholar 

  5. M. E. Vol’pin, V. S. Romanova, Z. N. Parnes, Mol. Cryst. Liq. Cryst. Sci. Technol., Sec. C, 1996, 7, 53.

    Google Scholar 

  6. C. Toniolo, A. Bianco, M. Maggini, G. Scorrano, M. Prato, M. Marastoni, R. Tomatis, S. Spisani, G. Palú, E. D. Blair, J. Med. Chem., 1994, 37, 4558.

    Article  CAS  Google Scholar 

  7. E. M. Belavtseva, E. V. Kichenko, V. S. Romanova, Z. N. Parnes, M. E. Vol’pin, Russ. Chem. Bull. (Engl. Transl.), 1996, 45, 831 [Izv. Akad. Nauk, Ser. Khim., 1996, 876].

    Article  Google Scholar 

  8. R. Sijbesma, G. Srdanov, F. Wudl, J. A. Castoro, C. Wilkins, S. H. Friedman, D. L. DeCamp, G. L. Kenyon, J. Am. Chem. Soc., 1993, 115, 6510.

    Article  CAS  Google Scholar 

  9. G. I. Timofeeva, E. F. Kuleshova, V. S. Romanova, Russ. Chem. Bull. (Engl. Transl.), 1997, 46, 472 [Izv. Akad. Nauk, Ser. Khim., 1997, 493].

    Article  CAS  Google Scholar 

  10. Z. S. Klemenkova, V. S. Romanova, V. A. Tsyryapkin, V. E. Muradan, Z. N. Parnes, B. V. Lokshin, M. E. Vol’pin, Mendeleev Commun., 1996, 6, 60.

    Article  Google Scholar 

  11. V. B. Luzhkov, V. S. Romanova, A. I. Kotel’nikov, Russ. Chem. Bull. (Int. Ed.), 2014, 63, 567 [Izv. Akad. Nauk, Ser. Khim., 2014, 567].

    Article  CAS  Google Scholar 

  12. R. Taylor, D. R. Walton, Nature, 1993, 363, 685.

    Article  CAS  Google Scholar 

  13. T. Yu. Dolinina, V. B. Luzhkov, Russ. Chem. Bull. (Int. Ed.), 2012, 61, 1631 [Izv. Akad. Nauk, Ser. Khim., 2012, 1614].

    Article  CAS  Google Scholar 

  14. V. G. Artyukhov, M. A. Nakvasina, Biologicheskie membrany: strukturnaya organizatsiya, funktsii, modifikatsiya fizikokhimicheskimi agentami [Biological Membranes: Structural Organization, Functions, and Modification by Physicochemical Agents], Izd-vo Voronezh. Un-ta, Voronezh, 2000, p. 232–234 (in Russian).

    Google Scholar 

  15. I. V. Veryovkina, M. M. Samed, V. Z. Gorkin, Biochim. Biophys. Acta, Enzymol., 1972, 258, 56.

    Article  CAS  Google Scholar 

  16. O. H. Lowry, N. J. Rosebrough, A. L. Farr, R. J. Randall, J. Biol. Chem., 1951, 193, 265.

    CAS  Google Scholar 

  17. O. P. Hamill, A. Marty, E. Neher, B. Sakmann, F. J. Sigworth, Pflugers Arch., 1981, 391, 85.

    Article  CAS  Google Scholar 

  18. M. Kaneda, H. Nakamura, N. Akaike, Neurosci. Res., 1988, 5, 299.

    Article  CAS  Google Scholar 

  19. H. K. Gershenfeld, P. E. Neumann, C. Mathis, J. N. Crawley, X. Li, S. M. Paul, Behav. Genet., 1997, 27, 201.

    Article  CAS  Google Scholar 

  20. A. Ennaceur, J. Delacour, Behav. Brain Res., 1988, 31, 47.

    Article  CAS  Google Scholar 

  21. J. C. Dodart, C. Mathis, A. Ungerer, NeuroReport, 1997, 8, 1173.

    Article  CAS  Google Scholar 

  22. R. S. Doody, S. I. Gavrilova, M. Sano, R. G. Thomas, P. S. Aisen, S. O. Bachurin, L. Seely, D. Hung, Lancet, 2008, 372, 207.

    Article  CAS  Google Scholar 

  23. Mediviation, Inc.; http://investors.medivation.com/releasedetail.cfm?ReleaseID=448818 (call 20.02.2015).

  24. I. V. Khritankova, M. S. Kukharskii, O. A. Lytkina, S. O. Bachurin, B. Yu. Shorning, Dokl. Biochem. Biophys. (Engl. Transl.), 2012, 446, 251 [Dokl. Akad. Nauk, 2012, 446, 471].

    Article  CAS  Google Scholar 

  25. S. H. Eckert, J. Eckmann, K. Renner-Sattler, G. P. Eckert, K. Leuner, W. E. Mueller, J. Alzheimer Dis., 2012, 31, 21.

    CAS  Google Scholar 

  26. J. W. Steele, S. Gandy, Autophagy, 2013, 9, 617.

    Article  CAS  Google Scholar 

  27. A. V. Ivachtchenko, E. B. Frolov, O. D. Mitkin, V. M. Kysil, A. V. Khvat, I. M. Okun, S. E. Tkachenko, Bioorg. Med. Chem. Lett., 2009, 19, 3183.

    Article  CAS  Google Scholar 

  28. V. V. Grigoriev, L. N. Petrova, T. A. Ivanova, R. A. Kotel’nikova, G. N. Bogdanov, D. A. Poletaeva, I. I. Faingold, D. V. Mishchenko, V. S. Romanova, A. I. Kotel’nikov, S. O. Bachurin, Biol. Bull., 2011, 38, 125 [Izv. Akad. Nauk, Ser. Biol., 2011, 163].

    Article  CAS  Google Scholar 

  29. V. S. Romanova, V. A. Tsyryapkin, Yu. A. Lyakhovetsky, Z. N. Parnes, M. E. Vol’pin, Russ. Chem. Bull. (Engl. Transl.), 1994, 43, 1090 [Izv. Akad. Nauk, Ser. Khim., 1994, 1154].

    Article  Google Scholar 

  30. Pat. CA 2687557; http://worldwide.espacenet.com

  31. C. Melchior, M. A. Collins, CRC Rev. Toxicol., 1982, 9, 313.

    Article  CAS  Google Scholar 

  32. H. G. Brunner, M. Nelen, X. O. Breakefield, H. H. Ropers, B. A. van Oost, Science, 1993, 262, 578.

    Article  CAS  Google Scholar 

  33. P. Simon, R. Dupuis, J. Costentin, Behav. Brain Res., 1994, 61, 59.

    Article  CAS  Google Scholar 

  34. V. V. Grigoriev, A. N. Proshin, A. S. Kinzirsky, S. O. Bachurin, Russ. Chem. Rev. 2009, 78, 485.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Institute of Problems of Chemical Physics of the Russian Academy of Sciences, 1 prosp. Akad. Semenova, 142432, Chernogolovka, Moscow Region, Russian Federation

    R. A. Kotel’nikova, A. V. Smolina, I. I. Faingold, D. V. Mishchenko, D. A. Poletaeva & A. I. Kotel’nikov

  2. Institute of Physiologically Active Compounds of the Russian Academy of Sciences, 1 Severnyi proezd, 142432, Chernogolovka, Moscow Region, Russian Federation

    V. V. Grigoriev, G. I. Van’kin, V. L. Zamoiskii, N. A. Markova & S. O. Bachurin

  3. A. N. Nesmeyanov Institute of Organoelement Compounds of the Russian Academy of Sciences, 28 ul. Vavilova, 119991, Moscow, Russian Federation

    V. S. Romanova

  4. School of Health Science and Healthcare Administration, University of Atlanta, Atlanta, 6685 Peachtree Industrial Boulevard, GA 30360, USA

    G. Aliev

Authors
  1. R. A. Kotel’nikova
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  2. V. V. Grigoriev
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  3. A. V. Smolina
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  4. I. I. Faingold
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  5. D. V. Mishchenko
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  6. G. I. Van’kin
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  7. V. L. Zamoiskii
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  8. D. A. Poletaeva
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  9. N. A. Markova
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  10. V. S. Romanova
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  11. A. I. Kotel’nikov
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  12. G. Aliev
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  13. S. O. Bachurin
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Corresponding author

Correspondence to R. A. Kotel’nikova.

Additional information

Dedicated to Academician of the Russian Academy of Sciences Yu. N. Bubnov on the occasion of his 80 birthday.

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 10, pp. 2375–2382, October, 2014.

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Kotel’nikova, R.A., Grigoriev, V.V., Smolina, A.V. et al. Design of a hybrid nanostructure based on fullerene C60 and biologically active substance for modeling physiological properties of compounds. Russ Chem Bull 63, 2375–2382 (2014). https://doi.org/10.1007/s11172-014-0750-0

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  • DOI: https://doi.org/10.1007/s11172-014-0750-0

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