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Synthesis and studies of biological activity of new 8-{[(adamant-1-yl)alkyl]amino}theophylline derivatives

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Abstract

Aminolysis of 8-chlorotheophylline with primary amines of adamantane family leads to new 8-[(adamant-1-yl)alkylamino]theophylline derivatives. Biological studies showed that one of the compounds obtained inhibited activity of recombinant HIV-1 reverse transcriptase in the concentration of 50 μmol L−1.

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Authors and Affiliations

  1. V. A. Engel’gardt Institute of Molecular Biology, Russian Academy of Sciences, 32 ul. Vavilova, 119991, Moscow, Russian Federation

    V. T. Valuev-Elliston, A. V. Ivanov & S. N. Kochetkov

  2. Volgograd State Technical University, 28 prosp. Lenina, 400131, Volgograd, Russian Federation

    E. N. Savel’ev, B. S. Orlinson, E. N. Gerasimov, E. K. Zakharova, L. L. Brunilina, I. A. Novakov & M. B. Navrotskii

Authors
  1. V. T. Valuev-Elliston
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  2. E. N. Savel’ev
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  3. A. V. Ivanov
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  4. B. S. Orlinson
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  5. E. N. Gerasimov
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  6. E. K. Zakharova
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  7. L. L. Brunilina
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  8. S. N. Kochetkov
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  9. I. A. Novakov
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  10. M. B. Navrotskii
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Corresponding author

Correspondence to V. T. Valuev-Elliston.

Additional information

Dedicated to Academician of the Russian Academy of Sciences M. P. Egorov on the occasion of his 60th birthday.

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 11, pp. 2544—2546, Novemer, 2013.

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Valuev-Elliston, V.T., Savel’ev, E.N., Ivanov, A.V. et al. Synthesis and studies of biological activity of new 8-{[(adamant-1-yl)alkyl]amino}theophylline derivatives. Russ Chem Bull 62, 2544–2546 (2013). https://doi.org/10.1007/s11172-013-0368-7

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  • DOI: https://doi.org/10.1007/s11172-013-0368-7

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