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Synthesis and selected properties of N-substituted pyrrolo[2,1-c]-1,3-diazacycloalkano[1,2-a]pyrazinones

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Abstract

The reactions of methyl α-(2-formyl-1H-pyrrol-1-yl)carboxylates with N-substituted aliphatic 1,2-, 1,3-, and 1,4-diamines afford new pyrrole-containing heterocyclic systems: 1,2,3,10b-tetrahydroimidazo[1,2-a]pyrrolo[2,1-c]pyrazin-5(6H)-ones, 1,3,4,11b-tetrahydro-2H-pyrrolo[2′,1′:3,4]pyrazino[1,2-a]pyrimidin-6(7H)-ones, and 1,2,3,4,5,12b-hexahydro-pyrrolo[2′,1′:3,4]pyrazino[1,2-a][1,3]diazepin-7(8H)-ones. The reduction of these compounds with different reagents was studied.

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Authors and Affiliations

  1. V. V. Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences, 8 ul. Baltiiskaya, 125315, Moscow, Russian Federation

    G. V. Mokrov, A. M. Likhosherstov, V. P. Lezina & T. A. Gudasheva

  2. A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 28 ul. Vavilova, 119991, Moscow, Russian Federation

    I. S. Bushmarinov & M. Yu. Antipin

Authors
  1. G. V. Mokrov
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  2. A. M. Likhosherstov
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  3. V. P. Lezina
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  4. T. A. Gudasheva
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  5. I. S. Bushmarinov
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  6. M. Yu. Antipin
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Correspondence to G. V. Mokrov.

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Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 6, pp. 1228–1239, June, 2010.

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Mokrov, G.V., Likhosherstov, A.M., Lezina, V.P. et al. Synthesis and selected properties of N-substituted pyrrolo[2,1-c]-1,3-diazacycloalkano[1,2-a]pyrazinones. Russ Chem Bull 59, 1254–1266 (2010). https://doi.org/10.1007/s11172-010-0230-0

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  • DOI: https://doi.org/10.1007/s11172-010-0230-0

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